摘要
目的 分析甲状腺乳头状微小癌（PTMC）患者应用血清促甲状腺激素（TSH）检测的价值。方法选取2014年1月—2016年1月该院收治甲状腺结节148例患者临床资料进行分析,按照肿瘤大小与病理结果分为三组,分别是分化型甲状腺癌组（32例）、PTMC组（21例）和良性甲状腺结节组（95例）,对三组TSH水平进行测定,且对其水平和结节内钙化、甲状腺外侵袭、淋巴结转移及肿瘤分期间关系进行对比。结果 分化型甲状腺癌组TSH水平（2.03±0.75）mU/L比良性甲状腺结节组（1.75±0.60）mU/L高,且伴随TSH水平升高,良性甲状腺结节组患病几率逐渐下降,分化型甲状腺癌组患病几率逐渐上升（P〈0.05）;分化型甲状腺癌组和PTMC组结节内钙化几率均比良性甲状腺结节组高,且PTMC组甲状腺外侵袭、淋巴结转移几率均比分化型甲状腺癌组低（P〈0.01）;肿瘤Ⅲ~Ⅳ期、有结节内钙化、有甲状腺外侵袭和有淋巴结转移患者TSH水平比Ⅰ~Ⅱ期、无结节内钙化、无甲状腺外侵袭和无淋巴结转移高（P〈0.01）。结论 血清TSH水平无法作为PTMC预测指标,但其和分化型甲状腺癌发生发展及结节内钙化有关,能够作为分化型甲状腺癌病灶恶化情况的重要参照指标,具有临床推广及应用价值。
Objective To analyze the application value of serum thyroid stimulating hormone in detection of patients with thyroid papillary tiny cancer. Methods clinical data of 158 cases of thyroid nodule patients treated in January 2014 - January 2016 at the hospital were analyzed retrospectively, and according to the tumor size and pathology results were divided into three groups. They were differentiated thyroid cancer group （32 cases}, PTMC group （21 cases） and benign thyroid nodule group （95 cases）, the three groups of TSH levels were measured, and its level and within the nodule caicification, thyroid invasion, lymph node metastasis and tumor points during relations were compared. Results TSH levels （2.03±0.75）mU in differentiated thyroid cancer group was higher than that in benign thyroid nodules （1.75±0.60） mU, and associated with elevated of TSH levels, benign thyroid nodule group probability gradually decline, differentiated thyroid cancer illness gradually increased （P（0.05）. Differentiated thyroid cancer group and the probability of nodular calcification in PTMC group were higher than benign thyroid nodule group, and the probability of invasion, lymph node metastasis outside thyroid PTMC group were lower than in differentiated thyroid cancer group （P〈0.01）. Tumor Ⅲ-Ⅳ period, nodular calcification within and outside the thyroid gland with the invasion and lymph node metastasis in patients with TSH levels were higher than Ⅰ-Ⅱ period, no nodal calcification within high, thyroid invasion and lymph node metastasis （P〈0.01）. Conclusions Serum TSH level cannot as PTMG predictor, but its occurrence and development is association with nodules and differentiated thyroid cancer with calcification within, and it can being as an important reference index of focal degeneration in differentiated thyroid cancer, have clinical popularizationand application value.
出处
《中国煤炭工业医学杂志》
2016年第12期1706-1709,共4页
Chinese Journal of Coal Industry Medicine
关键词
甲状腺结节
甲状腺乳头状微小癌
分化型甲状腺癌
促甲状腺激素
Thyroid nodule
Thyroid papillary tiny carcinoma
Differentiated thyroid cancer
Thyroid stimulating hormone
