摘要
目的:利用超声UFPWV技术检测兔的腹主动脉僵硬度以探讨该技术在定量评价血管壁弹性中的应用价值。方法:将45只雄性新西兰大白兔随机分为两组,一组35只采用高脂饮食(HFD)诱导法建立动脉硬化模型兔,另一组10只采用普通饲料喂养作为对照组。第0周和第24周末对所有兔子进行UFPWV检测获取腹主动脉弹性参数PWVBs和PWVEs。第24周末对腹主动脉进行组织病理学观察,有斑块的纳入斑块组,无明显斑块的纳入无斑块组。比较HFD组与对照组PWVBs和PWVEs及实验前后的自身对比,并进一步比较无斑块组、斑块组与对照组的PWVBs和PWVEs。绘制ROC曲线评价UFPWV在动脉硬化评估中的诊断效能。结果:第24周末HFD组PWVBs和PWVEs均高于对照组,且与第0周同组比较有明显增高(P<0.05);第24周末斑块组PWVBs和PWVEs均高于对照组和无斑块组(P<0.05),而无斑块组PWVBs和PWVEs均高于对照组(P<0.05)。PWVBs和PWVEs诊断AS的ROC曲线下面积分别为0.873和0.892。结论:动脉弹性会随着动脉管壁僵硬度的增加而降低,在动脉硬化早期管壁形态学改变之前即存在弹性的改变。UFPWV技术能够成功检测出早期动脉弹性的改变,在动脉硬化评估中有较高的诊断效能。
Objective： The purpose of this study was to explore the value of Uhrafast pulse wave velocity （UFPWV） tech nology in quantitative evaluation of arterial elasticity. Methods： Fortyfive male New Zealand white rabbits were divided into two groups, a group of 35 rabbits fed up with HFD to establish animal models of atherosclerosis and another group of 10 rab bits fed normal diet as the control group. UFPWV was used at the beginning and 24th week. Rabbits were sacrificed for pathological examination at 24th week. Rabbits with plaques were divided into plaque group, and the ones without were divid ed into nonplaque group. Parameters of the HFD group and the normal control group were compared, and self contrast was made. Meanwhile the parameters in the nonplaque group, the plaque group and the normal control group were compared at 24th week. The ROC curve was plotted to evaluate the efficacy of UFPWV technology. Result： Both PWVBs and PWVEs of the HFD group were significantly higher than the control group （P〈O.05）, and both the parameters of the plaque group were higher than the normal control group and the nonplaque group （P〈0.05）. There was also a increase in the nonplaque group compared with the control group （P〈0.05）. The area under the ROC curve of the parameters in diagnosing atherosclerosis were 0.873 and 0.892, respectively for PWVBs and PWVEs. Conclusion： Arterial elasticity might decrease paralleled with the in crease of arterial stiffness, and there＇s a decrease of arterial elasticity in the early stage of atherosclerosis before the morpho logical changes which could be successfully detected by the effective technology called UFPWV.
作者
任波
贺鹏
唐雯
熊妮
顾鹏
REN Bo;HE Peng;TANG Wen;XIONG Ni;GU Peng(Department of Ultrasound,Affiliated Hospital of North Sichuan Medical College,Nanchong Sichuan 637000,China)
出处
《中国临床医学影像杂志》
CAS
2018年第9期629-632,共4页
Journal of China Clinic Medical Imaging
基金
四川省医学科研青年创新课题<剪切波弹性成像对兔不同时期脂肪肝硬度的研究并分析硬度和内脂素的关系>(编号Q15006)
关键词
动脉硬化
主动脉
腹
兔
超声检查
多普勒
彩色
Arteriosclerosis
Aorta
abdominal
Rabbits
Ultrasonography
Doppler
color
