摘要
目的观察注射用牛肺表面活性剂联合经鼻持续气道正压通气(NCPAP)治疗新生儿呼吸窘迫综合征(NRDS)的疗效及安全性。方法选取郑州大学附属南阳市中心医院78例NRDS患儿,采用随机数表法分对照组和观察组,各39例。对照组行NCPAP治疗,观察组予以注射用牛肺表面活性剂+NCPAP治疗。对比两组临床疗效、动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)、pH水平及并发症发生情况。结果观察组治疗总有效率92.31%,高于对照组71.79%(P<0.05);治疗后观察组PaO_2、pH水平高于对照组,PaCO_2水平低于对照组(P<0.05)。结论注射用牛肺表面活性剂联合NCPAP治疗NRDS患儿,可提高治疗效果,改善血气状况,安全性高。
Objective To explore the efficacy and safety of Calf Pulmonary Surfactant for Injection combined with nasal continuous positive airway pressure（NCPAP） in the treatment of 39 cases of neonatal respiratory distress syndrome（NRDS）. Methods 78 children with NRDS in Nanyang Central Hospital affiliated to Zhengzhou University were randomly divided into groups, 39 cases in each group.The control group was treated with NCPAP and the observation group was treated with Calf Pulmonary Surfactant for Injection ＋NCPAP.The clinical efficacy, Results partial pressure of oxygen（PaO 2 ）, arterial partial pressure of carbon dioxide （PaCO 2 ）, pH level and complications were compared between the two groups.Results The total effective rate of the observation group was 92.31 % , which was higher than 71.79 % of the control group（ P 〈0.05）.After treatment, the levels of PaO 2 and pH in the observation group were higher than those in the control group, while the level of PaCO 2 was lower in the observation group than in the control group（ P 〈0.05）. Conclusion Calf Pulmonary Surfactant for Injection combined with NCPAP in the treatment of NRDS children can improve the therapeutic effect, and improve the blood gas condition.And it has high safety.
作者
冯园
FENG Yuan(Department of Pediatrics,Nanyang Central Hospital affiliated toZhengzhou University,Nanyang 473000,China)
出处
《国外医学（医学地理分册）》
CAS
2018年第4期331-333,共3页
Foreign Medical Sciences：Section of Medgeography
关键词
新生儿呼吸窘迫综合征
注射用牛肺表面活性剂
经鼻持续气道正压通气
血气分析
neonatal respiratory distress syndrome
calf pulmonary surfactant for injection
nasal continuous positive airway pressure
blood gas analysis
