摘要
目的探讨血清白介素34(IL-34)与T2DM及肥胖的相关性。方法选取研究对象99例,按照1998年WHO肥胖诊断标准分为正常体重组(NW组,n=32)和超重/肥胖组(OW组,n=67)。NW组按照1999年WHO糖尿病诊断标准分为无T2DM组(N-Con组,n=17)和T2DM组(N-T2DM组,n=15),OW组分为无T2DM组(O-Con组,n=33)及T2DM组(O-T2DM组,n=34)。检测各组血清IL-34、高敏C反应蛋白(hsC-RP)、FIns、FPG、TC、TG、LDL-C、HDL-C、HbA1c,测量SBP、DBP、WC、臀围(HC),记录年龄、性别,计算胰岛素抵抗指数(HOMA-IR)、BMI。对OW组中8例伴有糖尿病和5例不伴糖尿病的患者行腹腔镜Roux-en-Y胃旁路术(RYGB),术后1个月再次随访以上指标。结果各组血清IL-34浓度分别为(167.1±39.38)vs(170.71±35.68)vs(244.48±42.20)vs(208.67±46.50)ng/L。O-Con组高于N-Con、N-T2DM、O-T2DM组,同时O-T2DM组高于N-Con及N-T2DM组,N-Con组与N-T2DM组比较,差异无统计学意义(P>0.05)。Pearson相关分析显示,IL-34与hsC-RP、FIns、HOMA-IR、WC、HC、BMI呈正相关(r=0.672,0.442,0.566,0.678,0.476,0.651,P<0.01)。多元逐步回归分析显示,WC、BMI是IL-34的独立影响因素(β=0.434、0.321,P<0.01)。OW组8例代谢手术后随访1个月,血清IL-34水平、hsC-RP、HOMA-IR、BMI、WC较手术前下降,但只有HOMA-IR差异有统计学意义(P<0.01)。结论血清IL-34水平在肥胖人群中升高,可能参与IR,与机体炎症反应相关,和T2DM关系尚不明确。
Objective To explore the association between serum IL-34 and type 2 diabetes（T2 DM）and obesity. Methods A total of 99 subjects were enrolled in this study and divided into two groups according to WHO obesity diagnostic criteria 1998：normal weight group（NW group,n=32）and overweight/obesity group（OW group,n=67）.NW group was then divided into two subgroups according to WHO diabetes diagnostic criteria 1999：Non-T2 DM subgroup（N-Con group,n=17）and T2 DM subgroup（N-T2 DM group,n=15）.And OW group was also divided into two subgroups：Non-T2 DM subgroup（O-Con group,n = 33）and T2 DM subgroup（O-T2 DM group,n = 34）.Serum IL-34 concentration,hsC-RP,FIns,FPG,TC,TG,LDL-C,HDL-C,and HbA1 c were measured in each group.Systolic blood pressure（SBP）,diastolic blood pressure（DBP）,waist circumference（WC）,hip circumference（HC）,age,and sex were recorded.HOMA-IR and BMI were calculated.In OW group,laparoscopic Roux-en-Y gastric bypass（RYGB）surgery was performed in 3 patients with diabetes and 5 patients without diabetes,and follow up for at least one month. Results Serum IL-34 levels were（167.1±39.38）vs（170.71±35.68）vs（244.48±42.20）vs（208.47±46.50）ng/L in each group.Serum IL-34 level was higher in O-Con group than in N-Con,N-T2 DM and O-T2 DM group.Serum IL-34 level was higher in O-T2 DM group than in N-Con and N-T2 DM group.Serum IL-34 level was not significantly different between N-Con group and N-T2 DM group（P〈0.05）.Pearson correlation analysis showed that serum IL-34 concentration was positively correlated with hsC-RP,FIns,HOMA-IR,WC,HC,BMI（r=0.672,0.442,0.566,0.678,0.476,0.651,P〈0.01）.Multiple stepwise regression analysis showed that WC and BMI were independent influencing factors for serum IL-34 concentration（β=0.434,0.321,P〈0.01）.After one month of surgery,hsC-RP,BMI,serum IL-34 concentration,WC and HOMA-IR were all decreased in the 8 patients,but only the changes of HOMA-IR reached the statistical significance. Conclusion The serum IL-34 co
作者
张欣欣
陆璧
成兴波
ZHANG Xinxin,LU Bi,CHENG Xingbo(Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2018年第8期632-636,共5页
Chinese Journal of Diabetes
基金
上海市糖尿病重点实验室开放课题(SHKLD-KF-1403)
关键词
肥胖
糖尿病
2型
血清白介素34
胰岛素抵抗指数
体质指数
Obesity
Diabetes mellitus
type 2
IL-34
Homeostasis model assessment of insulinresistance
Body mass index
