摘要
目的探讨血清白细胞介素(IL)-34、补体C1q/肿瘤坏死因子相关蛋白13(CTRP13)与不稳定型心绞痛(UA)合并2型糖尿病(T2DM)的关系。方法选取150例行冠状动脉造影检查的患者,结合临床表现和实验室检查分为UA合并糖尿病(UA+T2DM)组50例、单纯UA(UA)组50例、单纯T2DM(T2DM)组50例,选取同期健康体检者50例为对照组。采用酶联免疫吸附试验测定血清IL-34和CTRP13水平。分析各组临床指标差异,相关性分析探究UA+T2DM组IL-34、CTRP13与腰围(WC)、体质量指数(BMI)、空腹血糖(FPG)、超敏C反应蛋白(hs-CRP)及Gensini积分的关系,受试者工作特征(ROC)曲线分析IL-34、CTRP13及两者联合对UA合并T2DM的诊断价值。结果血清IL-34水平在对照组、T2DM组、UA组、UA+T2DM组依次升高,血清CTRP13水平在对照组、UA组、T2DM组、UA+T2DM组依次降低,UA+T2DM组Gensini积分显著高于UA组(均P<0.05)。相关性分析显示,在UA+T2DM组,IL-34与WC、FPG、hs-CRP及Gensini积分呈正相关,与CTRP13呈负相关;CTRP13与hs-CRP、FPG及Gensini积分呈负相关(均P<0.05)。ROC曲线结果显示,血清IL-34、CTRP13及两者联合诊断UA合并T2DM的曲线下面积分别为0.784(0.716~0.852)、0.820(0.759~0.882)和0.847(0.787~0.906)。结论UA合并T2DM患者血清IL-34水平较高、CTRP13水平较低,IL-34和CTRP13对UA合并T2DM及其冠状动脉病变严重程度有一定的诊断及预测价值。
Objective To investigate the correlation between IL-34,CTRP13 and unstable angina(UA)with type 2 diabetes mellitus(T2DM).Methods A total of 150 patients admitted to the Affiliated Hospital of Chengde Medical University were collected and divided into 3 groups according to the clinical data and coronary angiography results:UA+T2DM group(n=50),UA group(n=50)and T2DM group(n=50),and healthy people who had physical examination at the same period were selected as the control group(n=50).The serum levels of IL-34 and CTRP13 were detected by ELISA.The differences of clinical indexes were compared between the four groups.The correlation between IL-34,CTRP13 and WC,FPG,hs-CRP,Gensini score in the UA+T2DM group were analyzed.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic values of IL-34 and CTRP13 for UA with T2DM.Results The serum levels of IL-34 increased in the control group,T2DM group,UA group and UA+T2DM group in turn(all P<0.05).The serum levels of CTRP13 decreased in the control group,UA group,T2DM group and UA+T2DM group in turn(all P<0.05).The Gensini score was significantly higher in UA+T2DM group than that of UA group(P<0.05).Correlation analysis showed that serum IL-34 level was positively correlated with WC,FPG,hs-CRP and Gensini score in UA+T2DM group,but negatively correlated with CTRP13(all P<0.05).The serum level of CTRP13 was negatively correlated with hs-CRP,FPG and Gensini score(all P<0.05).The ROC curve showed that the areas under the curves of IL-34,CTRP13 and joint indicators were 0.784(0.716-0.852),0.820(0.759-0.882)and 0.847(0.787-0.906)in the diagnosis of UA with T2DM.Conclusion The serum level of IL-34 is higher and the serum level of CTRP13 is lower in UA patients with T2DM.The serum levels of IL-34 and CTRP13 have predictive values for the diagnosis and the severity of coronary artery disease in UA with T2DM.
作者
刘慧卿
金凤表
吕苗苗
高宇
侯瑞田
LIU Hui-qing;JIN Feng-biao;LYU Miao-miao;GAO Yu;HOU Rui-tian(Department of Cardiac Electrophysiology,the Affiliated Hospital of Chengde Medical University,Chengde 067000,China;Department of Endocrinology,the Affiliated Hospital of Chengde Medical University,Chengde 067000,China)
出处
《天津医药》
CAS
北大核心
2021年第9期987-991,共5页
Tianjin Medical Journal
