摘要
目的:探究益气温阳通络中药联合氨磷汀预防胃肠道肿瘤患者奥沙利铂神经毒性的临床效果。方法:选取2015年1月~2017年5月福建省龙岩市第二医院82例胃肠道恶性肿瘤患者,随机数字表法分组,各41例。2组均予以奥沙利铂、亚叶酸钙、氟尿嘧啶联合化疗方案,对照组给予氨磷汀,实验组给予氨磷汀+益气温阳通络中药,共治疗6个周期。观察2组神经毒性发生情况,对比治疗前后感觉神经传导速度(SCV)、神经传导速度(MCV)。结果:(1)治疗后2个周期、4个周期、6个周期实验组周围神经毒性发生率低于对照组(P<0.05),治疗后6个周期实验组周围神经毒性在1~3级所占比例低于对照组(P<0.05);(2)治疗前后2组腓神经、正中神经的MCV比较,无显著差异(P>0.05),治疗后实验组腓神经、正中神经的SCV高于对照组(P<0.05)。结论:益气温阳通络法联合氨磷汀可有效预防胃肠道肿瘤患者奥沙利铂神经毒性,发挥周围神经保护作用。
Objective： To investigate the clinical effect of Yiqi Wenyang Tongluo Chinese medicine combined with Amifostine in preventing Oxaliplatin neurotoxicity in patients with gastrointestinal cancer. Methods： 82 cases of gastrointestinal cancer in Longyan Second Hospital of Fujian from January 2015 to May 2017 were randomly divided into groups, 41 cases in each group. Based on the two groups treated with oxaliplatin, calcium folate and fluorouracil, the control group was treated with ammoniacine, and the experimental group was treated with ammoniacine＋Yiqi Wenyang Tongluo Chinese medicine. Both groups were treated for a total of 6 cycles. The neurotoxicity of two groups were observed. The sensory nerve conduction velocity（SCV）and nerve conduction velocity（MCV）were compared before and after treatment. Results（1）The incidence of neurotoxicity in the experimental group was lower than that in the control group after 2 cycles, 4 cycles, and 6 cycles of treatment（P〈0.05）. After 6 cycle of treatment, the proportion of peripheral neurotoxicity in the grade 1~3 in the experimental group was lower than that in the control group（P〈0.05）.（2） There was insignificant difference in MCV of peroneal nerve and median nerve between the two groups before and after treatment（P〉0.05）. After treatment, the SCV of the peroneal nerve and median nerve in the experimental group was higher than that in the control group（P〈0.05）. Conclusion Yiqi Wenyang Tongluo Chinese medicine combined with Amifostine can effectively prevent Oxaliplatin neurotoxicity in patients with gastrointestinal cancer, and protect the peripheral nerve.
作者
刘可期
孙畋
许香贵
阙晓梅
LIU Keqi;SUN Tian;XU Xianggui;QUE Xiaomei(The Second Hospital of Longyan City,Fujian Longyan 364000,Chin)
出处
《中医药临床杂志》
2018年第7期1240-1242,共3页
Clinical Journal of Traditional Chinese Medicine
关键词
胃肠道恶性肿瘤
氨磷汀
益气温阳通络中药
奥沙利铂
神经毒性
Gastrointestinal cancer
Amifostine
Yiqi Wenyang Tongluo Chinese medicine
Oxaliplatin
Neurotoxicity
