摘要
目的：探讨氨磷汀改善奥沙利铂药物神经毒性的疗效。方法：选择96例胃肠道肿瘤患者,随机分为2组各48例,观察组给予奥沙利铂联合氨磷汀治疗,对照组仅给予奥沙利铂治疗,6个疗程后对两组神经毒性进行评估。结果：经2、4、6个周期的化疗,观察组1~2级神经毒性发生率分别为10.41%、14.58%、6.26%,明显低于对照组（50.00%、58.33%、68.75%）,P均〈0.05。经4、6个周期的化疗观察组3~4级神经毒性发生率明显低于对照组（4.17%VS 29.17%,6.25%VS 25.00%,P均〈0.05）;观察组有效率（CR＋PR）为79.17%,临床受益率（CR＋PR＋SD）为87.50%,对照组分别为83.33%、91.67%,（79.17%VS 83.33%;87.50%VS 91.67%,χ~2=0.274,0.447;P均〉0.05）。结论：氨磷汀能预防奥沙利铂药物神经毒性,对周围神经产生保护作用,同时不会降低奥沙利铂类药物疗效。
Objective To explore the effects of amifostine on improving neurotoxicity induced by oxaliplat-in.Methods Ninty-six cases of patients with gastrointestinal cancers were randomly divided into observationgroup and control group, 48 patients in each group. The patients in the observation group were treated with oxaliplatin combined with amifostine, but those in the control group were only treated with oxaliplatin. After 6 cycles of the treatment, the neurotoxicity of patients in two groups was evaluated.Results After 2, 4, 6 cycles of chemotherapy, the occurrence rates of grade 1~2 of peripheral neurotoxicity in the observed group was significantly lower than that of the control group（[10.41%）VS（50.00%）,（14.58%）VS（58.33%）,（6.26%）VS（68.75%）,P〈0.05]. The occurrence rates of grade 3~4 peripheral neurotoxicity in the observation group was also significantly lower than that of the control group（[4.17%）VS（29.17%）（,6.25%）VS（25.00%）, P〈0.05]. The efficiency（Cr＋PR） and the clinical benefit rate（Cr＋PR＋SD） in the observation group were higher than those in the control grouCp, [（79.17）%VS（83.33%）;（87.50%）VS（91.67%）], but the difference was not statistically significant（P〉0.05）.on clusionAmifostine can improve the neurotoxicity induced by oxaliplatin and have protective effect on peripheral nerve, while it will not reduce the clinical curative effect of oxaliplatin medicine.
出处
《中国中西医结合外科杂志》
CAS
2016年第3期246-248,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
氨磷汀
奥沙利铂
神经毒性
胃癌
Amifostine
oxaliplatin
neurotoxicity
gastric cancers
