摘要
目的探讨热敏灸防治奥沙利铂引起的化疗相关性神经毒性的效果。方法选取60例使用奥沙利铂化疗的患者,随机分为治疗组与对照组,每组30例。治疗组采用热敏灸治疗,对照组无特殊处理。比较2组患者CIPN的发生率、治疗前后的神经传导速度以及治疗前后手麻症状。结果治疗组CIPN总发生率为52%,对照组为50%,2组发生率的差异无统计学意义。治疗前2组患者的正中神经、尺神经及桡神经的MCV、SCV组间差异均无统计学意义(P>0.05);治疗6周期后治疗组患者受损正中神经、桡神经MCV均较治疗前明显增快(P<0.05),改善幅度显著高于对照组(P<0.05)。治疗组减轻奥沙利铂引起的手麻症状也优于对照组(P<0.05)。结论热敏灸的治疗能有效缓解奥沙利铂引起的化疗相关性神经毒性病变,具有临床应用价值。
Objective To observe the effect of heat sensitive moxibustion prevention of oxaliplatin induced chemothera- py-related neurotoxieity. Methods 60 patients treated with oxaliplatin chemotherapy were randomly divided into the treatment group and the control group,30 cases in each group,the treatment group received heat sensitive moxibustion therapy, the control group received no special treatment, occurrence rate of chemotherapy-related neurotoxicity, nerve conduction velocity and symp- toms of numbness before and after the treatment were compared between the 2 groups. Results In the treatment group and the control group,total incidence rate of chemotherapy-related neurotoxicity were 52% and 50%, the difference was not statistically significant between the 2 groups. Before treatment, median nerve, ulnar nerve and radial nerve MCV and SCV between the 2 group had no statistically significant difference （ P 〉 0.05 ） ; after 6 cycles of treatment, median nerve, radial nerve MCV of the treatment group signii^cantly increased compared with before treatment （P 〈 0.05 ） ,the improvement rate was significantly higher than that of the control group （ P 〈 0.05 ）. In the treatment group, relief of oxaliplatin induced numbness symptoms was superior to the con- trol group （ P 〈 0.05 ）. Conclusion Thermal moxibustion therapy can effectively relieve the oxaliplatin induced chemotherapy related neurotoxic lesions, and it has clinical application value.
出处
《实用癌症杂志》
2016年第8期1264-1267,共4页
The Practical Journal of Cancer
基金
江西省卫生厅科技项目(编号:2011A060)
江西省科技计划项目(编号:20132BBG70058)
关键词
热敏灸
奥沙利铂
化疗相关性神经毒性
Heat-sensitive moxibustion
Oxaliplatin
Chemotherapy-related neurotoxicity
