摘要
目的探讨血清中核因子-κB(NF-κB)和肿瘤坏死因子-α(TNF-α)与多囊卵巢综合征(PCOS)患者糖脂代谢指标的相关性。方法选择80例PCOS患者为研究组,同期来院就诊的80例非PCOS不孕症患者为对照组。根据体质量指数(BMI)是否≥25 kg/m2,将研究组分为PCOS肥胖亚组(A组,40例)、PCOS非肥胖亚组(B组,40例);对照组分为非PCOS肥胖亚组(C组,40例)和非PCOS非肥胖亚组(D组,40例)。检测静脉血NF-κB、TNF-α及血糖血脂相关指标,并对各因素间关系采用Spearman相进行关性分析。结果 A组稳态胰岛素评价指数(HOMA-IR)、空腹胰岛素(FIN)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)水平指标明显高于B组(P值分别为0.022、0.036、0.044、0.023)、C组(P值分别为0.014、0.029、0.021、0.018)及D组(P值分别为0.007、0.021、0.014、0.003),B组HOMA-IR及FIN指标高于C组(P值分别为0.041、0.033)及D组(P值分别为0.030、0.017);A组血清中总胆固醇(TC)水平高于D组(P=0.023);B组血清中TG和LDL-C水平高于D组(P值分别为0.032、0.026);A组血清中高密度脂蛋白胆固醇(HDL-C)水平低于D组(P=0.001);A组血清中NF-κB水平[(655.59±273.41)IU/L]高于B组[(502.84±165.48)IU/L](P=0.034)、C组[(352.10±132.45)IU/L](P=0.019)及D组[(319.62±112.57)IU/L](P=0.005),B组血清中NF-κB水平高于C组(P=0.039)及D组(P=0.031);A组血清中TNF-α水平[(86.18±18.32)ng/L]高于B组[(66.86±22.71)ng/L](P=0.042)、C组[(58.40±17.90)ng/L](P=0.029)及D组[(54.67±22.34)ng/L](P=0.013),B组血清中TNF-α水平高于D组(P=0.038);在相关性分析中显示,PCOS患者中NF-κB及TNF-α均与BMI、FIN、HOMA-IR、TG、LDL-C等指标有相关性(P<0.05),且NF-κB与TNF-α也有相关性(P<0.05)。结论 TNF-α可能与NF-κB相互作用共同参与PCOS的糖脂代谢紊乱的发生及发展,为临床治疗PCOS提供了新的思路。
Objective To explore the correlation between the serum inflammatory markers of nuclear factor-κB（NF-κB）, tumor necrosis factor-alpha（TNF-α） and related indicators on glucose metabolism and lipid metabolism in women with polycystic ovary syndrome（PCOS）. Methods Eighty patients with PCOS were selected in the observe group, and 80 infertile patients without PCOS were collected in control group. The patients were subdivided to 4 groups according to body mass index（BMI） levels, including the obese（BMI ≥ 25 kg/m2） patients with PCOS（group A, n=40）, the non-obese（BMI〈25 kg/m2） patients with PCOS（group B, n=40）, the obese（BMI ≥ 25 kg/m2） patients without PCOS（group C, n=40）, and the non-obese（BMI〈25 kg/m2） patients without PCOS（group D, n=40）. The serum samples were collected from all the patients for detecting TNF-α, NF-κB and related indicators on glucose metabolism and lipid metabolism. The parameters were analyzed and compared among the four groups by using two independent samples t-test and Spearman correlation analysis. Results The indexes of homeostasis model assessment-insulin resistance（HOMA-IR） and fasting insulin（FIN） in group A were signifcantly higher than those in group B（P were 0.022 and 0.036, respectively）, group C（P were 0.014 and 0.029, respectively） and group D（P were 0.007 and 0.021, respectively）, while they were signifcantly higher in group B than those in group C（P were 0.041 and 0.033, respectively）, and group D（P were 0.030 and 0.017, respectively）. Serum total cholesterol level（TC） in group A was higher than that in group D（P=0.023）. The indexes of triglyceride（TG） and low-density lipoprotein cholesterol（LDL-C） in group A were higher than those in group B（P were 0.044 and 0.023, respectively）, group C（P were 0.021 and 0.018, respectively） and group D（P were 0.014 and 0.003, respectively）, while they were higher in group B than those in group D（P were 0.032 and 0.026, respective
作者
张燕
杨玉清
包俊华
郝苗苗
李萍
Zhang Yan;Yang Yuqing;Bao Junhua;Hao Miaomiao;Li Ping(Reproductive Center of Yinchuan Maternal and Child Healtheare Center,Hnchuan 750000,Chin)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2018年第6期485-489,共5页
Chinese Journal of Reproduction and Contraception
基金
宁夏回族自治区科技支撑计划项目(2015BY102)~~
