摘要
目的:探究多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者血清表皮型脂肪酸结合蛋白(epidermal fatty acid binding protein,E-FABP)、血管生成素样蛋白2(angiopoietin-like protein,Angptl 2)、阿立新A(Orexin-A)水平与肥胖和糖脂代谢的关系。方法:回顾性分析本院2019年11月-2020年11月收治的89例PCOS患者的临床资料,依据体质量指数(body mass index,BMI)将其分为PCOS肥胖组(49例,BMI≥25 kg/m2)和PCOS非肥胖组(40例,BMI<25 kg/m2),另取同期来本院进行健康体检的38例女性作为健康对照组,对比三组患者E-FABP、Angptl 2、Orexin-A、糖代谢指标[空腹胰岛素(fasting insulin,FINS)、2 h胰岛素(insulin 2 h,INS 2 h)、空腹血糖(fasting plasma glucose,FPG)、2 h血糖(glucose 2 h,GLU 2 h)]、脂代谢指标[甘油三酯(triglycerides,TG)、总胆固醇(total cholesterol,TC)、游离脂肪酸(free fatty acid,FFA)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)]水平并分析其相关性。结果:(1)PCOS肥胖组患者E-FABP、Angptl 2水平高于PCOS非肥胖组与健康对照组,Orexin-A水平低于PCOS非肥胖组与健康对照组(P<0.05)。(2)PCOS肥胖组患者FINS、INS 2 h、FPG及GLU 2 h水平均高于PCOS非肥胖组与健康对照组(P<0.05)。(3)PCOS肥胖组患者TG、TC、FFA、LDL-C水平均高于PCOS非肥胖组与健康对照组,HDL-C水平低于PCOS非肥胖组与健康对照组(P<0.05)。(4)E-FABP水平与肥胖(r=0.514)、FINS(r=0.680)、INS 2 h(r=0.643)、FPG(r=0.509)、GLU 2 h(r=0.738)、TG(r=0.764)、TC(r=0.575)、FFA(r=0.630)、LDL-C(0.667)指标均呈显著正相关(P<0.05);Angptl 2水平与肥胖(r=0.468)、FINS(r=0.663)、INS 2 h(0.619)、FPG(r=0.622)、GLU 2 h(r=0.651)、TG(r=0.705)、TC(r=0.638)、FFA(r=0.623)、LDL-C(r=0.751)指标均呈显著正相关(P<0.05);Orexin-A水平与HDL-C(r=0.691)显著正相关,与肥胖(r=-0.720)、FINS(r=-0.419)、INS 2 h(r=-0.432)指标呈显著负相关(P<0.05)。�
Objective:To explore the relationship between serum epidermal fatty acid binding protein (E-FABP),angiopoietin-like protein 2 (Angptl 2),and alixin A (Orexin-A) levels and obesity,glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS).Method:The clinical data of 89 PCOS patients admitted to our hospital from November 2019 to November 2020 were retrospectively analyzed.According to the body mass index (BMI),they were divided into the PCOS obese group (49 cases,BMI ≥25 kg/m2) and the PCOS non-obese group (40 cases,BMI <25 kg/m2),38 women who came to our hospital for physical examination during the same period were selected as the healthy control group.Compared the three groups of patients with E-FABP,Angptl 2,Orexin-A,glucose metabolism indicators such as fasting insulin (FINS),2 h insulin (INS 2 h),fasting plasma glucose (FPG),2 h blood glucose (GLU 2 h),lipid metabolism indicators such as glycerol triglycerides (TG),total cholesterol (TC),free fatty acid (FFA),low-density lipoprotein cholesterol (low-density lipoprotein cholesterol,LDL-C),high-density lipoprotein cholesterol (HDL-C) levels and analyzed its correlation.Result:(1) The levels of E-FABP and Angptl 2 in the PCOS obese group were higher than those in the PCOS non-obese group and the healthy control group,and the Orexin-A levels were lower than the PCOS non-obese group and the healthy control group (P<0.05).(2) The FINS,INS 2 h,FPG and GLU 2 h of the PCOS obese group were higher than those of the PCOS non-obese group and the healthy control group (P<0.05).(3) the levels of TG,TC,FFA,and LDL-C in the PCOS obese group were higher than those of the PCOS non-obese group and the healthy control group,the HDL-C level was lower than the PCOS non-obese group and the healthy control group (P<0.05).(4) E-FABP level and obesity (r=0.514),FINS (r=0.680),INS 2 h(r=0.643),FPG (r=0.509),GLU 2 h (r=0.738),TG (r=0.764),TC (r=0.575),FFA (r=0.630),LDL-C (0.667) indicators were all significantly positively correlated (P<0.05);Angptl 2 level were s
作者
高华
王孟丽
伍庆龄
GAO Hua;WANG Mengli;WU Qingling(Songzi People's Hospital,Songzi 434200,China)
出处
《中外医学研究》
2021年第22期188-191,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
多囊卵巢综合征
表皮型脂肪酸结合蛋白
血管生成素样蛋白2
阿立新A
肥胖
糖脂代谢
Polycystic ovary syndrome
Epidermal fatty acid binding protein
Angiopoietin-like protein 2
Orixin A
Obesity
Glucose and lipid metabolism
