摘要
白内障手术是目前世界上最常见、最成熟的眼科手术之一。手术包括摘除混浊的晶状体及人工晶状体的植入,可以较好地恢复患者视力。后囊膜混浊(posterior capsular opacification,PCO),又称继发性白内障,是白内障手术后常见的并发症之一,严重影响了手术的治疗效果。在白内障手术后2~5 a,由PCO导致的视力下降患者占20%~40%。PCO是一种纤维变性疾病。研究PCO的发生机制已经成为一项重要的医学课题。目前证实手术后晶状体赤道部及前囊下残余的晶状体上皮细胞通过增殖、迁移、上皮间质转化成为成纤维细胞和肌成纤维细胞,伴随细胞外基质的合成最终导致了PCO的发生。一系列生长因子及信号通路参与到PCO的形成和发展过程并发挥了关键作用。本文对与PCO发生相关的分子调控通路的最新知识进行了总结,并探讨了干扰PCO发生的可能途径。
Cataract surgery is one of the most common and mature eye surgeries in the world,and the procedures include the removal of turbid lens and intraocular lens（ IO L） implantation,which can better restore the patient＇s vision. Posterior capsular opacification（ PCO）,also known as secondary cataract,is one of the most common complications after cataract surgery,seriously affecting the surgical efficacy. Two to five years after cataract surgery,PCO-induced loss of vision accounted for 20%-40% of patients. PCOis a fibrotic disease,and its mechanism has become an important medical topic. It has been demonstrated that the residual lens epithelial cells（ LECs） in the equatorial and anterior capsule region after surgery have become fibroblasts and myofibroblasts via proliferation,migration and epithelial-mesenchymal transition（ EM T） accompanied by extracellular matrix（ EC M） synthesis,eventually leading to the occurrence of PCO. A series of grow th factors and signaling pathw ays participate and play a key role in the initiation and development of PCO. In this review,recent advances in molecular regulation pathw ays associated with PCO will be summarized,and the possible methods interfering with PCO will be explored.
作者
刘婷婷
包秀丽
LIU Ting-Ting, BAO Xiu-Li(From the Department of Ophthalmology,the Affiliated Hospital of Inner Mongolia Medical University,Huhhot 010050,Imer Mongdia Autonomous Region,Chin)
出处
《眼科新进展》
CAS
北大核心
2018年第6期592-596,共5页
Recent Advances in Ophthalmology
基金
国家自然科学基金(编号:81360145)~~
关键词
白内障
后囊膜混浊
分子调控通路
cataract
posterior capsular opacification
molecular pathways
