摘要
目的:系统评价Acry Sof直角方边人工晶状体和Sensar前圆后方人工晶状体对术眼后囊膜混浊的预防作用。方法:计算机检索Pub Med(1980/2015-09)、CBM(1990/2015-09)、VIP(1989/2015-09)、CNKI(1990/2015-09)和wanfang Data(1990/2015-09),收集年龄相关性白内障超声乳化联合植入Acry Sof三片式人工晶状体与植入Sensar三片式人工晶状体术后后囊膜混浊发生情况的随机对照试验,由两名评价者按照纳入与排除标准筛选研究、提取资料和质量评价后,采用Rev Man 5.2软件进行Meta分析。结果:共纳入5项研究,总计1 036眼(Acry Sof组553眼,Sensar组483眼),随访时限6mo^2a,Meta分析结果显示:(1)Acry Sof组术后PCO发生率显著低于Sensar组(OR=0.67,95%CI:0.45~0.99,P=0.04);(2)两种人工晶状体植入后术眼后囊膜Nd:YAG激光切开术施行率比较,无统计学差异(OR=0.57,95%CI:0.32~1.02,P=0.06)。(3)2a以上长期随访亚组分析中,Acry Sof组PCO发生率显著低于Sensar组(OR=0.60,95%CI:0.40~0.91,P=0.02),两组人工晶状体术后后囊膜激光切开术施行率比较,无统计学差异(OR=0.60,95%CI:0.33~1.09,P=0.09)。结论:Acry Sof三片式人工晶状体相比于Sensar三片式人工晶状体显示出较强的预防后囊膜混浊作用。
AIM： To compare posterior capsule opacification （PCO） after phacoemulsification cataract surgery with implantation of two different hydrophobic acrylic intraocular lenses （IOLs）. METHODS： Such databases as PubMed （1980-Sep 2015 ）, CBM （ 1990- Sep 2015 ）, VIP （ 1989 - Sep 2015 ）, CN KI （1990- Sep 2015） and WanFang Data （1990- Sep 2015） were searched to collect the randomized controlled trials （RCTs） about AcrySof 3-piece IOL vs Sensar 3-piece IOL for PCO or incidence of Nd： YAG laser capsulotomy. According to the inclusion and exclusion criteria, two reviewers independently screened the literatures, extracted data and assessed the quality of the included studies, then Meta - analysis was conducted using RevMan 5.2 software. RESULTS- A total of 5 RCTs involving 1036 eyes （AcrySof group： 553 eyes, Sensar group： 483 eyes） were included, with a follow-up duration of 6mo - 2a. The results of Meta-analysis showed that： （1） the incidence of PCO was significantly lower in AcrySof group than that in Sensar group（ OR= 0.67,95% CI.0. 45 - 0.99, P= 0.04） ;（2） the incidence of Nd：YAG laser capsulotomy after surgeries was similar between AcrySof group and Sensar group（ OR= 0. 57,95% CI：0. 32 - 1.02, P= 0.06） ; （3） in an above 2a long- term follow- up subgroup analysis, AcrySof group indicated a significantly lower incidence of PCO（OR= 0.60,95% CI：0.40 - 0.91, P= 0.02）, while the Nd： YAG laser capsulotomy incidence was similar between the two groups（ OR=0. 60,95% CI：0. 33 - 1.09, P =0.09）. CONCLUSION ： AcrySof 3- piece IOL seems to have a stronger preventive effect on PCO than Sensar 3-piece IOL. For the quantity limitation of the included studies, this conclusion still needs to be further proved by more high-quality RCTs.
出处
《国际眼科杂志》
CAS
2016年第4期642-646,共5页
International Eye Science
关键词
后囊膜混浊
后发性白内障
人工晶状体
META分析
系统评价
posterior capsule opacification
after -cataract
intraocular lenses
Meta - analysis
systematic review
