摘要
克山病是一种地方性扩张型心肌病。目前疫情得到有效控制,但病因至今尚未完全明确。近年来,遗传学在扩张型心肌病病因中占有重要地位,一些研究提示遗传学可能是克山病的病因之一,克山病的发病与相关基因如HLA-DRB1、GPx-1和SCN5A等基因多态性或突变有关。现从克山病的遗传学方面进行综述,为克山病病因的深入后续研究提供新的思路和方向。
Keshan disease （KD） is an endemic eardiomyopathy. Although the current prevalence of KD has been controlled, the etiology is still not clear. Recent increasing studies indicated that HLA-DRB1, GPx-land SCN5A single nueleotide polymorphisnls or gene mutation were involved in KD. The aim of this paper is to describe the status genetic etiology progress in KD and provide in-depth follow-up studies for the causes of KD.
作者
徐理飞
叶兴雨
罗蓉
李小平
XU Lifei;YE Xingyu;LUO Rong;LI Xiaoping(Chengdu Medical College Xindu Campus,Chengdu 610500,Sichuan,China;Department of Cardiology,Sichuan Provincial People＇s Hospital;The Affiliated Hospital of Medical School,University of Electronic Science and Technology of China,Chengdu 610000,Sichuan,Chin)
出处
《心血管病学进展》
CAS
2018年第4期671-673,共3页
Advances in Cardiovascular Diseases
基金
国家自然基金项目(81470521
81500297)
国家级大学生创新课题(201613705002)
关键词
克山病
病因学
遗传学
Keshan disease
Genetics
Etiology
