摘要
目的 了解陕西克山病人HLA -DRB1基因多态性的特征。方法 应用PCR -SSOP技术对 118例克山病人进行HLA -DRB1基因分型。结果 鉴定了克山病人HLA -DRB1位点的 10种等位基因 ,其中高频率分布的有DR15、DR4、DR9。结论 提供了一套比较完整准确的陕西克山病人DRB1等位基因的基因频率 ,对群体遗传和疾病关联研究具有参考意义。
Objective To investigate polymorphism of HLA-DRB1 in Keshan disease patients in Shaanxi Province.Methods Polymerase chain reaction-sequence specific oligonucleotide robes(PCR-SSOP)were used to determine HLA-DRB1 genotypes of Keshan disease patients of Shaanxi Province.Results 10 alleles of DRBI were detected in this study.Conclusions This study has obtained a more comprehensive and accurate data set of allele frequencies of HLA-DRB1 in Chinese Keshan disease patients in Shaanxi Province,which may be of significance in the studies on population genetics and disease association.
出处
《中国地方病防治》
CAS
2003年第6期327-328,共2页
Chinese Journal of Control of Endemic Diseases
基金
陕西省科技攻关项目 (No .2 0 0 0k1 4 -g1 4 )
