摘要
目的:观察补骨祛痛方治强直性脊柱炎的临床疗效及其对炎性因子的作用。方法:选取87例强直性脊柱炎患者随机分为2组,对照组43例,观察组44例,对照组患者口服来氟米特片,柳氮磺吡啶肠溶片,甲氨蝶呤片;观察组在对照组基础上加服补骨祛痛方,2组均连续治疗3个月。比较2组患者治疗前后血清中的C反应蛋白(CRP)、血沉(ESR)、肿瘤坏死因子-α(TNF-α)及白介素-6(IL-6)水平;比较治疗前后2组BASDAI、BASFI评分及活动功能评分;采用中医证候积分评价2组临床疗效。结果:2组患者给药后与给药前比较,ESR、CRP、TNF-α及IL-6水平显著降低(P<0.05);并且观察组比对照组的ESR、CRP、TNF-α及IL-6水平降低的幅度更明显(P<0.05)。治疗后2组患者BASDAI和BASFI评分显著下降,并且观察的BASDAI和BASFI评分显著低于对照组(P<0.05);治疗后2组的枕墙距、指地距、扩胸度、脊柱痛评分均显著降低(P<0.05),Schober试验指标明显上升(P<0.05),并且治疗后观察组的枕墙距、指地距、扩胸度、脊柱痛评分显著较对照组低(P<0.05),Schober试验指标显著较对照组高(P<0.05)。对照组的总有效率为79.1%,观察组的总有效率为90.1%,2组的临床疗效具有显著性差异(P<0.05)。结论补骨祛痛方治疗强直性脊柱炎疗效确切,其机制可能与调节体内炎性因子相关。
Objective： To explore the therapeutic effect of using Bugu Qutong Recipe in the treatment of ankylosing spondyli- tis and its effect on inflammatory factors. Methods： 87cases of ankylosing spondylitis were randomly divided into 2groups, 43cases in controlled group, 44cases in observation group, the controlled group was treated with Leflunomide Tablets, Sulfasalazine Enter- ic-coated Tablets, Methotrexate Tablets ; The observation group was treated with Bugu Qutong Decoction on the basisi of the con- trolled group, the 2groups were treated for 3months. Comparison of 2groups of patients before and after treatment of serum C reac- tive protein （ CRP）, erythroeyte sedimentation rate （ESR） , tumor necrosis factor alpha （TNF-alpha） and interleukin-6 （ IL- 6 ） level; Scores of 2groups of BASDAI, BASFI score and function before and after treatment; The TCM syndrome score to evalu- ate the clinical efficacy of the 2groups. Results： After treatment, the levels of ESR, CRP, TNF-alpha and IL-6in the 2groups were significantly lower than those in the controlled group （P〈0. 05 ） , and the ESR, CRP, TNF-alpha and IL-61evels in the ob- servation group decreased more significantly than those in the controlled group （P〈0. 05 ）. After the treatment of 2patients with BASDAI and BASFI scores were significantly decreased, and the observation of BASDAI and BASFI were significantly lower than the controlled group （P〈0. 05 ） ; The 2groups after treatment, pillow wall distance, mean distance, chest expansion, spinal pain scores were significantly lower （ P〈O. 05 ）, Schober test index significantly increased （ P〈0. 05 ）, and after treatment in the ob- servation group, pillow wall distance, mean distance, chest expansion, spinal pain scores were significantly lower than the con- trolled .group （ P〈0. 05 ） , Schober test index was significantly higher than the controlled group （ P〈0. 05 ）. The total effective rate of the controlled group was 79. 1% , the total effective rate of
作者
李力
徐照
赵晶晶
吴春叶
LI Li;XU Zhao;ZHAO Jingling;et al(Rheumatology Department of Traditional Chinese Medicine, Tianjin 254Hospital （Tianjin 300142, China)
出处
《四川中医》
2018年第6期141-144,共4页
Journal of Sichuan of Traditional Chinese Medicine
