摘要
目的探讨左卡尼汀辅助抗菌药物对感染性心内膜炎患者血清肌钙蛋白I(cTnⅠ)、降钙素原(PCT)及红细胞沉降率(ESR)影响。方法选取2014年5月-2016年6月收治的42例原发性感染性心内膜炎患者为研究对象,随机分为对照组和左卡尼汀组,每组21例。均予吸氧、纠正心功能等基础治疗,对照组予头孢替唑钠及炎琥宁治疗,左卡尼汀组在上述基础上予左卡尼汀治疗。检测相关血清生化指标、ESR及体温变化和临床效果。结果与治疗前比较,两组血清cTnⅠ及ESR水平降低,血清PCT、CRP、白细胞介素-6(IL-6)水平降低,WBC、MPV降低,体温有所降低但无差异;左卡尼汀组cTnⅠ、ESR、PCT、CRP、IL-6、WBC和MPV分别为(1.32±0.16)ng/ml、(13.46±1.72)min、(0.78±0.10)ng/ml、(38.36±5.24)mg/L、(52.34±7.17)mmol/L、(9.43±1.26)×10~9/L和(8.17±1.12)fl低于对照组(P<0.001);左卡尼汀组疗效优于对照组(P=0.036)。结论左卡尼汀辅助常规抗菌药物治疗感染性心内膜炎疗效较好,具有一定的临床价值。
OBJECTIVE To investigate the effects of L-carnitine adjuvant antibiotics on serum cTnⅠ,procalcitonin and ESR in patients with infective endocarditis.METHODS A total of 42 cases of patients with primary infective endocarditis from May 2014 to Jun.2016 were selected and randomly divided into control group and L-carnitine group,with 21 cases in each group.Both groups were treated with the basic treatment of oxygen and correction of cardiac function.Patients in control group were given ceftezole sodium and potassium sodium dehydroandroan drographolide succinate,and patients in L-carnitine group were treated more with L-carnitine on the basis of the control group.Changes of serum biochemical parameters,ESR and body temperature and clinical effect were detected.RESULTS Compared with before treatment,the levels of serum cTnⅠ and ESR decreased,the levels of serum PCT,CRP and interleukin-6（IL-6）decreased,the levels of WBC and MPV decreased in the two groups,and the body temperature decreased with no difference.Levels of cTnⅠ,ESR,PCT,CRP,IL-6,WBC and MPV of Lcarnitine group were（1.32±0.16）ng/ml,（13.46±1.72）min,（0.78±0.10）ng/ml,（38.36±5.24）mg/L,（52.34±7.17）mmol/L,（9.43±1.26）×109/L and（8.17±1.12）fl,respectively,which were significantly lower than those of control group（P〈0.001）,and the clinical effect of L-carnitine group was significantly better than those of control group（P=0.036）.CONCLUSIONL-carnitine adjuvant conventional antibiotics has better curative effect in the treatment of infective endocarditis,and it is worthy of further promotion and discussion.
作者
潘嘉西
章敏学
姜进克
郑巨克
吕良冬
付荣泉
PAN Jia-xi;ZHANG Min-xue;JIANG Jin-ke;ZHENG Ju-ke;LYU Liang-dong;FU Rong-quan(The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou , Zhejiang 325200, Chin)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2018年第12期1798-1801,共4页
Chinese Journal of Nosocomiology
基金
浙江省自然科学基金资助项目(LY14H030010)
