摘要
目的探究左卡尼汀联合头孢菌素类抗菌药物及炎琥宁注射液治疗感染性心内膜炎(IE)患者的临床疗效。方法选取我院2017年6月至2019年4月IE患者86例,根据治疗方案不同分组,各43例。对照组给予头孢菌素类抗菌药物联合炎琥宁注射液治疗,观察组于对照组基础上加用左卡尼汀。对比两组疗效及治疗前后血清降钙素原(PCT)、肌钙蛋白Ⅰ(cTnI)、C反应蛋白(CRP)、白介素6(IL-6)、红细胞沉降率(ESR)水平及平均血小板体积、白细胞计数。结果观察组总有效率93.02%较对照组74.42%高(P<0.05);治疗后观察组血清cTnI水平、ESR较对照组低(P<0.05);治疗后观察组血清PCT、IL-6、CRP水平较对照组低(P<0.05);治疗后观察组平均血小板体积、白细胞计数较对照组低(P<0.05)。结论左卡尼汀联合头孢菌素类抗菌药物及炎琥宁注射液治疗IE患者,可减轻炎症,改善血清cTnI、ESR水平,疗效显著。
Objective To investigate the clinical efficacy of L-Carnitine combined with cephalosporin antibacterial drugs and Yanhuning injection in the treatment of patients with infective endocarditis(IE).Methods Eighty-six patients with IE were selected from June 2017 to April 2019 in our hospital.According to different treatment schemes, there were 43 patients each. The control group was treated with cephalosporin antibacterial drugs combined with Yanhuning injection, and the observation group was given L-carnitine on the basis of the control group. Compare the curative effect of the two groups and the serum levels of procalcitonin(PCT), troponin Ⅰ(cTnI), C-reactive protein(CRP),interleukin 6(IL-6), red blood cell sedimentation rate(ESR), and average platelet volume,White blood cell count.Results The total effective rate of observation group was 93.02% higher than that of control group 74.42%(P<0.05).After treatment, the serum cTnI level and ESR of observation group were lower than those of control group(P<0.05). After treatment, serum PCT, IL-6, The CRP level was lower than that in the control group(P<0.05);the average platelet volume and white blood cell count in the observation group were lower than those in the control group after treatment(P<0.05).Conclusion L-carnitine combined with cephalosporins antibacterial drugs and Yanhuning injection can reduce inflammation, improve serum cTnI and ESR levels, and has significant effects.
作者
贾周
丁学智
JIA Zhou;DING Xue-zhi(Department of Cardiology,Qixian People's Hospital,Qixian 456750 China;Department of Cardiology,Hebi People's Hospital,Hebi 458030 China)
出处
《内蒙古医学杂志》
2020年第2期143-145,共3页
Inner Mongolia Medical Journal
