摘要
p53是一种重要的肿瘤抑制因子,是迄今发现与人类肿瘤相关性最高的分子之一。超过50%的人类肿瘤含有p53基因突变。因此,p53是肿瘤治疗中的重要分子靶点。p53依赖的细胞凋亡是其抑制肿瘤的重要机制之一。然而,最近研究发现,p53不仅参与细胞凋亡,还与程序性细胞坏死、细胞自噬以及铁诱导的细胞死亡等细胞死亡途径相关。促使肿瘤细胞死亡是肿瘤治疗的重要目标。因此,进一步了解p53与细胞死亡之间的关系,将有助于探索以p53为靶点的肿瘤治疗和p53相关肿瘤细胞耐药机制。
p53,an important tumor suppressor,is closely related to human cancers. More than 50% of human cancers contain p53 mutations. Thus,it is an important molecular target in cancer therapy. p53-dependent apoptosis is one of the important mechanisms of tumor suppression. However,recent studies have shown that p53 is not only involved in apoptosis but also associated with other types of cell deaths such as programmed necrosis,autophagy and iron-induced cell death（ ferroptosis）. Promoting tumor cell death is the ultimate goal of cancer therapies. Therefore,it is necessary to investigate the various functions of p53 in different modes of cell death,which will contribute to further studies on p53-targeted cancer therapy and p53-related tumor cell chemotherapy resistance.
作者
任汐鹰
刘勤献
王海英
REN Xi-Ying;LIU Qin-Xian;WANG Hai-Ying(Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2018年第6期588-594,共7页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金(No.81472627)资助~~
