摘要
血管性认知功能障碍(VCI)是指由于脑血管病危险因素(如高血压病、糖尿病和高脂血症等)、显性(如脑梗死和脑出血等)或非显性脑血管病(如白质疏松和慢性脑缺血)引起的从轻度认知损害到痴呆的一大类综合征。认知功能是机体认识及获取知识、对其进行学习记忆加工的过程。因此建立可靠的动物模型、较好模拟人类脑血管病的发病过程,是研究血管性认知功能障碍发病机制和治疗作用的关键。故建立一种操作简便、可重复、死亡率低、评价指标简便的动物模型意义显著。本文就常用VCI动物模型建造方法进行简要综述,为今后选择简便有效的动物模型提供借鉴。
Vascular cognitive impairment（ VCI） is due to cerebrovascular disease risk factors（ such as hypertension,diabetes and hyperlipidemia,etc.）,dominant（ such as cerebral infarction and cerebral hemorrhage,etc.） or nondominant cerebrovascular disease（ Such as white matter loose and chronic cerebral ischemia） caused by mild cognitive impairment to a large class of dementia syndrome. Cognitive function is the process of understanding and acquiring knowledge and memory and processing. Therefore,it is significant to establish an animal model that is easy to operate,repeatable,has a low mortality rate,and is easy to evaluate. This article briefly reviews the common VCI animal model construction methods and provides a reference for future selection of simple and effective animal models.
作者
李欧
沙中玮
吴双
李志敏
徐建
LI O;SHA Zhong-wei;WU Shuang;LI Zhi-min;XU Jian(Shanghai Municipal Hospital of Traditional Chinese Medicine affiliated to Shanghai TCM University Shanghai 200071, China)
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2018年第4期567-568,F0003,F0004,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
上海市卫计委(ZY3-LCPT-1-1010)-上海市神志病中医临床基地建设项目
上海市卫计委(20151052)-上海市重点薄弱学科建设-中医老年病学
上海市自然科学基金资助项目(17ZR1428100)-基于BDNF-TrkB/PI3K/AKT通路探讨疏肝法抑制VCI大鼠海马神经元凋亡
