摘要
目的了解乐山市五通桥区建筑工地流动人口麻疹暴发疫情波及范围和传播链,探讨疫情的发生原因,为制定防治策略提供科学的依据。方法采用流行病学调查方法对病例进行调查核实,采集患者血清和咽拭子标本,进行血清学、病原学和分子流行病学特征检测明确诊断。结果 2017-03-28/2017-04-12在乐山市同一工地发生4例麻疹确诊病例,麻疹Ig M检测均阳性,其中2例患者咽拭子用荧光定量PT-PCR法做麻疹病毒核酸和风疹病毒核酸检测,麻疹病毒核酸均为阳性,病毒分离和基因型鉴定,均为麻疹病毒阳性,基因型为H1a。结论 4名患者均为外籍人员,由外来病例输入传播所致,经采取综合防治措施,未发生二代病例,疫情得到有效控制。
Objective To investigate the coverage and transmission chain of a measles outbreak in the mobile population on a construction site in Wutongqiao District of Leshan and discuss the causes of the outbreak so as to provide a scientific basis for developing prevention and treatment strategies. Methods The cases were investigated and verified using epidemiological investigation methods. Patients＇ serum and throat swab samples were collected, and serological, etiological and molecular epidemiologieal tests were conducted to confirm the diagnosis. Results During the period from March 28 to April 12, 2017, four cases were confirmed on a construction site in Leshan. Measles IgM test was positive in all cases. Fluorescent quantitative PT - PCR was conducted for nucleic acid assay of measles virus and rubella virus on throat swabs of two patients. Both cases were measles virus nucleic acid positive. Virus isolation and genotype identification showed the cases were all measles virus positive, and the genotype was Hl a. Conclusion All of the four patients were from other places; the outbreak was caused by external cases. Following administration of comprehensive prevention and treatment measures, no second - generation case has occurred, and the epidemic situation has been effectively controlled.
作者
高俊英
雷毛英
许子敏
李良州
王进
GAO Junying, LEI Maoying, XU Zimin , LI Liangzhou, WANG Jin Wutongqiao(District Center for Disease Control and Prevention, Leshan 614800, Sichuan Province, Chin)
出处
《寄生虫病与感染性疾病》
CAS
2018年第1期24-27,共4页
Parasitoses and Infectious Diseases
关键词
麻疹
暴发
流行病学调查
流动人口
measles
outbreak
epidemiological investigation
mobile population
