摘要
目的探讨替格瑞洛对年龄>75岁PCI患者术后抗血小板治疗的疗效及安全性。方法选择年龄>75岁急性冠状动脉综合征行PCI患者120例,随机分为观察组60例(阿司匹林+替格瑞洛)和对照组60例(阿司匹林+氯吡格雷)。PCI术后随访1年,比较2组主要不良心血管事件、出血性事件及药物不良反应发生率及全因病死率。结果观察组PCI术后1年无支架内血栓形成,发生心肌梗死2例,心绞痛5例,死亡3例。对照组PCI术后1年支架内血栓形成4例,心肌梗死3例,心绞痛6例,死亡4例。观察组PCI术后1年支架内血栓发生率明显低于对照组(0%vs 6.7%,P<0.05)。观察组轻微呼吸困难发生率明显高于对照组(10.0%vs 0%,P<0.05)。结论替格瑞洛可有效预防年龄>75岁患者PCI术后支架内血栓形成,同时不增加出血风险,安全有效。
Objective To study the effect and safety of ticagrelor on platelet in 75 years old patients undergoing PCI.Methods One hundred and twenty75 years old patients with acute coronary syndrome undergoing PCI were randomly divided into observation group treated with aspirin＋ticagrelor（n=60）and control group treated with aspirin＋clopidogrel（n=60）.They were followed up for 1 year after PCI.The major adverse cardiovascular events（MACE）,bleeding events,drug-related side effects and all-cause mortality were compared between the two groups.Results No instent thrombosis occurred in any patients,myocardial infarction occurred in 2 patients,angina pectoris occurred in 5 patients and 3 patients died in observation group after 1 year of PCI.Instent thrombosis occurred in 4 patients,myocardial infarction occurred in 3 patients,angina pectoris occurred in 6 patients,and 4 patients died in control group after 1 year of PCI.The incidence of instent thrombosis was significantly lower while that of mild dyspnea was significantly higher in observation group than in control group（0%vs 6.7%,10.0%vs 0%,P0.05）.Conclusion Ticagrelor can effectively prevent instent thrombosis and does not increase the risk of bleeding in 75 years old patients after PCI.
作者
蔡林
张峰
荣玉栋
张菁
王慧珍
金文敏
王小飞
Cai Lin, Zhang Feng, Rong Yudong, Zhang Jing,Wang H,tdzhen, Jin Wenmin, Wang Xiaofei(Department of Geriatrics, Tianjin First Central Hespital, Tianjin 300192 ,Chin)
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2018年第3期234-236,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
天津市卫计委科技基金(2015KZ037)
