摘要
目的评价不稳定型心绞痛患者经皮冠状动脉介入治疗(PCI)术后长期服用小剂量替格瑞洛的安全性和有效性。方法将我院收治的300例行PCI术的不稳定型心绞痛患者随机分为对照组(45例)和观察组(45例)。在常规治疗基础上,对照组服用常规剂量替格瑞洛(90 mg),观察组服用小剂量替格瑞洛(60 mg)。比较两组干预效果。结果术后6、12个月,观察组ADP诱导下PAR、AA诱导下PAR均高于对照组(P<0.05)。术后6、12个月,两组心功能指标无显著差异(P>0.05)。术后12个月,观察组出血事件总发生率低于对照组(P<0.05)。术后6、12个月,两组MACE总发生率均无显著差异(P>0.05)。结论不稳定型心绞痛患者PCI术后长期服用小剂量替格瑞洛也能有效促进心功能恢复,不增加MACE发生率,同时PAR较好,出血事件发生率降低。
Objective To evaluate the safety and efficacy of long term use of low-dose tegrilol in patients with unstable angina after PCI.Methods A total of 300 patients with unstable angina undergoing PCI admitted in our hospital were randomly divided into control group(45 cases)and observation group(45 cases).On the basis of conventional treatment,the control group was given routine dose of ticagrelor(90 mg),and the observation group was given low-dose ticagrelor(60 mg).The intervention effects were compared between the two groups.Results At 6 and 12 months after operation,PAR induced by ADP and PAR induced by AA in the observation group were higher than those in the control group(P<0.05).There were no significant differences in cardiac function indexes between the two groups at 6 and 12 months after operation(P>0.05).At 12 months after operation,the total incidence of bleeding events in the observation group was lower than that in the control group(P<0.05).There were no significant differences in the incidence of MACE between the two groups at 6 and 12 months after operation(P>0.05).Conclusion The long term use of low-dose tegrarol after PCI can also effectively promote the recovery of cardiac function without increasing the cumulative incidence of MACE.Meanwhile,the PAR is better and the incidence of bleeding events reduce.
作者
杨登魁
王端乐
YANG Dengkui;WANG Duanle(Xianyang Hospital of Yan'an University,Xianyang 712000,China)
出处
《临床医学研究与实践》
2020年第28期66-67,70,共3页
Clinical Research and Practice
