摘要
目的探讨吡格列酮联合二甲双胍对肥胖型多囊卵巢综合征(PCOS)的治疗效果及对性激素和脂代谢水平的影响。方法回顾性分析2015年3月至2016年5月在广东省深圳市罗湖区妇幼保健院接受治疗的肥胖型PCOS患者的临床资料。根据其治疗方式分为对照组和观察组,对照组给予二甲双胍治疗,观察组给予吡格列酮联合二甲双胍治疗。观察两组患者治疗前后性激素、血清人五聚素3(PTX3)、脂代谢、糖代谢的差别。结果观察组治疗后血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)均显著低于治疗前(t值分别为3.114、3.908、2.998、3.989,均P<0.05),且观察组治疗后显著低于对照组治疗后(t值分别为2.888、3.520、2.765、3.357,均P<0.05)。观察组治疗后口服75g葡萄糖粉后2h血糖水平(P2hBG)、空腹胰岛素水平(FINS)、空腹胰岛素抵抗指数稳态模型(HOMA-IR)均显著下降(t值分别为2.454、3.650、3.786,均P<0.05),而对照组效果不明显(t值分别为0.787、0.776、0.554,均P>0.05)。两组患者治疗后低密度脂蛋白(LDL)均显著下降(t值分别为2.675、2.098,均P<0.05),而观察组治疗后效果优于对照组(t值分别为2.462、4.011,均P<0.05)。观察组治疗后高密度脂蛋白(HDL)显著上升、甘油三酯(TG)显著下降(t值分别为2.023、2.825,均P<0.05)。结论吡格列酮联合二甲双胍对肥胖型多囊卵巢综合征有较好的治疗效果,可明显改善激素、血脂和血糖代谢水平,具有临床应用价值。
Objective To investigate the therapeutic effect of pioglitazone combined with metformin on obese women with polycystic ovary syndrome（PCOS）and its influence on sex hormone and lipid metabolism.Methods The clinical data of patients with obese PCOS treated in Maternal and Child Health Care Hospital of Luohu District in Shenzhen City of Guangdong Province from March2015 to May 2016 was retrospectively analyzed.According to treatment methods,the patients were divided into control group and observation group.Control group was given metformin treatment,and observation group was treated with pioglitazone combined with metformin.Differences in sex hormones,serum pentraxin 3（PTX3）,lipid metabolism,glucose metabolism before and after treatment in two groups were observed.Results Serum follicle stimulating hormone（FSH）,luteinizing hormone（LH）,estradiol（E2）and testosterone（T）in observation group after treatment were significantly lower than those before treatment（t value was3.114,3.908,2.998 and 3.989,respectively,all P〈0.05）,and these indexes in observation group after treatment were significantly lower than those in control group after treatment（t value was 2.888,3.520,2.765 and 3.357,respectively,all P〈0.05）.Blood glucose 2 hafter oral 75 g of glucose powder（P2 hBG）,fasting insulin（FINS）,and empty stomach homeostasis model of assessment for insulin resistance index（HOMA-IR）in observation group were significantly decreased after treatment（t value was 2.454,3.650 and 3.786,respectively,all P〈0.05）,which did not decline obviously in control group（t value was 0.787,0.776 and 0.554,respectively,all P〈0.05）.Low density lipoprotein（LDL）decreased significantly after treatment in both groups（t value was 2.675 and 2.098,respectively,both P〈0.05）,while treatment effect in observation group was better than that in control group（t value was 2.462 and 4.011,respectively,both P〈0.05）.High density lipoprotein（HDL）was significantly increased and triglyceride�
出处
《中国妇幼健康研究》
2017年第12期1710-1713,共4页
Chinese Journal of Woman and Child Health Research
基金
深圳市罗湖区科技创新局资助项目[编号:罗科(2015)26号]
关键词
吡格列酮
二甲双胍
肥胖
多囊卵巢综合征
性激素
血脂
pioglitazone
metformin
obesity
polycystic ovary syndrome （PCOS）
sex hormones
blood lipid
