摘要
目的:探讨百令胶囊联合炔雌醇环丙孕酮、二甲双胍对多囊卵巢综合征(PCOS)患者脂代谢、胰岛素抵抗的影响。方法:2014年11月~2017年4月间在本院接受治疗的PCOS患者108例,回顾治疗方案,并分为接受常规治疗的常规组67例,接受百令胶囊联合常规治疗的百令胶囊组41例。常规组患者接受炔雌醇环丙孕酮、二甲双胍治疗,百令胶囊组患者接受百令胶囊联合炔雌醇环丙孕酮、二甲双胍治疗。对比两组治疗前后脂代谢、胰岛素抵抗相关指标、炎症因子含量的差异。结果:治疗前,两组血清中脂代谢、胰岛素抵抗相关指标、炎症因子含量的差异无统计学意义(P>0.05)。治疗后,百令胶囊组血清中高密度脂蛋白胆固醇(HDL-C)的含量较常规组高(P<0.05),低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)的含量较常规组低(P<0.05);血清中胰岛素抵抗相关指标空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)的水平较常规组低(P<0.05);血清中炎症因子白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、脂联素(APN)、瘦素(LEP)的含量较常规组低(P<0.05)。结论:PCOS患者接受百令胶囊联合炔雌醇环丙孕酮、二甲双胍治疗,可有效改善机体脂代谢水平、抑制胰岛素抵抗。
Objective:To investigate the effect of Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin on lipid metabolism and insulin resistance in patients with polycystic ovary syndrome(PCOS).Methods:A total of 108 patients with PCOS who were treated in our hospital between November 2014 and April 2017 were reviewed and divided into routine group(n=67)who received routine therapy and Bailing capsule group(n=41)who received Bailing capsule combined with routine therapy.Routine group received ethinylestradiol and cyproterone acetate and metformin therapy,and Bailing capsule group were treated with Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy.The differences in the levels of lipid metabolism,insulin resistance indexes as well as inflammatory factors were compared between the two groups before and after treatment.Results:There was no statistically significant difference in serum levels of lipid metabolism,insulin resistance-related indexes and inflammatory factors between the two groups before treatment.After treatment,serum HDL-C content of Bailing capsule group was higher than that of routine group whereas LDL-C and TC contents were lower than those of routine group;serum insulin resistance-related indexes FINS and HOMA-IR levels were lower than those of routine group;serum inflammatory cytokines IL-6,TNF-α,APN and LEP contents were lower than those of routine group.Conclusion:Bailing capsule combined with ethinylestradiol and cyproterone acetate and metformin therapy can effectively improve the lipid metabolism level and inhibit the insulin resistance in patients with PCOS.
出处
《海南医学院学报》
CAS
2018年第2期224-227,共4页
Journal of Hainan Medical University
基金
黔科计(2016056)~~
关键词
多囊卵巢综合征
百令胶囊
脂代谢
胰岛素抵抗
Polycystic ovary syndrome
Bailing capsule
Lipid metabolism
Insulin resistance
