摘要
目的 :观察老年冠心病不同类型患者中肿瘤坏死因子α(TNF -α)、白细胞介素 1β(IL - 1β)水平变化及其与C反应蛋白 (CRP)之间的关系 ,进一步探讨急性冠状动脉综合征临床识别和预测的炎症指标。方法 :采用放射免疫分析测定血清TNF -α、IL - 1β和CRP的浓度。 结果 :急性冠脉综合征患者 (ACS)TNF -α和IL- 1β水平均显著高于对照组 (p <0 0 5 ;p <0 0 1)和稳定性冠心病患者 (p <0 0 5 ;p <0 0 1)。ACS患者CRP水平(7 99± 11 9)mg L显著高于SCHD组 (2 71± 5 4 5 )mg L ,p <0 0 5和对照组 (0 99± 1 5 )mg L ,p <0 0 1。CRP水平与TNF -α呈显著正相关 (r=0 5 4 5 ,p <0 0 1) ;与IL - 1β亦呈明显正相关 (r=0 31,p <0 0 5 )。 结论 :老年冠心病患者细胞因子表达异常与炎性标志物CRP密切相关 ,提示可能与急性冠脉综合征的发生有关 。
Objective To investigate the relationship between plasma TNF-α, IL-1β and CRP levels in aged patients with coronary heart disease and to define the inflammation marker which might recognize and predict acute coronary syndrome. Methods Radioimmunoassay was used to detect plasma levels of TNF-α, IL-1β and CRP. Results Plasma levels of TNF-α and IL-β in patients with acute coronary syndrome (ACS) were significantly higher than those in controls ( p<0 05;p<0 01 ) and stable coronary heart disease (SCHD) ( p<0 05;p<0 01 ). Plasma CRP levels in patients with ACS (7 99±11 9mg/L) were also significantly higher than those in controls (0 99±1 5mg/L; p <0 01) and patients with SCHD (2 71±5 45mg/L; p <0 05). There was positive correlation beteen CRP level and TNF-α ( r=0 0545; p <0 01) as well as IL-β ( r=0 31, p <0 05). Conclusion The abnormal expression of cytokines in aged patients with coronary heart disease was correlative to inflammation marker CRP, which suggested that the abnormal expression to the occur rence of acute coronay syndrome and mignr serve as a marker of unstable atheroscleorsis plaque.
出处
《放射免疫学杂志》
CAS
2002年第4期205-207,共3页
Journal of Radioimmanology
