摘要
目的:探讨终末期肾病(ESRD)患者氧化应激水平及其影响因素。方法:选取尿毒症患者57例,测定血浆丙二醛(MDA)、氧化修饰低密度脂蛋白(Ox-LDL)和晚期蛋白氧化产物(AOPP)水平。结果:绦末期肾病患者MDA、Ox-LDL和AOPP水平较正常人明显升高(P<0.01)。有心血管并发症者较无心血管并发症者升高(P<0.01)。应用血管紧张素转换酶抑制剂(ACEI)治疗的患者比不用ACEI治疗患者的MDA、Ox-LDL和AOPP降低。结论:终末期肾病患者血浆氧化应激水平较正常人明显升高,有心血管并发症者升高更明显。应用ACEI治疗可能降低终末期肾病患者氧化应激的水平。
Objective：To investigate the level of oxidative stress in patients with end stage renal disease（ESRD） and analyze the correlation factors. Methods：The level of malondialhehyde（MDA）, oxidized low - density lipoprotein（ox - LDL） and advanced oxidized protein products（AOPP） of 57 uremic patients were detected. The detected results of the patients were compared with those of the normal subjects. Results：The level of MDA, ox - LDL and AOPP of ESRD patients were significantly higher than those of the normal subjects（P〈0. 01 ）. The patients with cardiovascular diseases had a higher levels of MDA, ox - LDL and AOPP than the patients without cardiovascular diseases（.P〈0.01 ）. The level of MDA, ox - LDL and AOPP of ESRD patients taking angiotensin - converting enzyme inhibitors（ACEIs） were higher than those of ESRD patients not taking ACEIs. Conclusion： The level of oxidative stress in ESRD patients is higher than that in the normal subjects and ACEIs can alleviate the oxidative stress induced by ESRD.
出处
《西南国防医药》
CAS
2008年第3期346-348,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
终末期肾病
氧化应激
血管紧张素转换酶抑制剂
end stage renal disease
oxidative stress
angiotensin - converting enzyme inhibitor
