摘要
目的探讨自身免疫性甲状腺疾病患者血清中自身抗体水平及其对疾病诊断的价值。方法选取健康体检正常人群50例,Graves病(GD)患者48例,桥本甲状腺炎(HT)患者36例,检测血清中TGAb、TPOAb及TRAb的水平。其中TGAb及TPOAb采用化学发光法;TRAb采用电化学发光法。定性结果比较采用卡方(χ~2)检验,定量结果采用t检验。结果 GD组TRAb的检出高于HT组,而HT组TGAb和TPOAb高于GD组,差异有统计学意义(P<0.01或P<0.05)。GD组TGAb、TPOAb和TRAb均高于对照组,差异有统计学意义(P<0.01)。HT组TGAb和TPOAb高于对照组(P<0.01),两组间TRAb的差异无统计学意义。GD组的TPOAb值低于HT组,TRAb值高于HT组,差异均有统计学意义(P<0.05或P<0.01)。GD组与对照组比较,FT3、FT4高于对照组,TSH低于对照组,差异具有统计学意义(P<0.01)。HT组与对照组比较,TSH高于对照组,差异具有统计学意义(P<0.01)。结论检测甲状腺自身抗体对自身免疫性甲状腺疾病特别是对GD及HT疾病的诊断、鉴别诊断、治疗及预后判断具有一定的价值。
Objective To explore the level of serum autoantibodies in patients with autoimmune thyroid diseases and its diagnostic value of diseases.Methods Serum samples were obtained from 48 Graves patients,36 Hashimoto＇s thyroiditis patients and 50 normal controls.Levels of TGAb and TPOAb were measured by chemiluminescent immunoassay,and TRAb was measured by electrochemical luminescence immunoassay.The categorical data were compared using chi-squre（χ-2）test and the measurement data were compared using t-test.Results The detection of GD group was higher than HT group in the level of TRAb and HT group was higher than GD group in the level of TPOAb,TGAb,the difference was statistically significant（P〈0.01 or P〈0.05）.GD group in the level of TGAb,TPOAb and TRAb were higher than the control group,the difference was statistically significant（P〈0.01）.HT group in the level of TGAb and TPOAb were higher than the control group（P〈0.01）,the difference between the two groups in the level of TRAb was not statistically significant.The level of TPOAb in GD group was lower than HT group,and the level of TRAb was higher than HT group,and the difference was statistically significant（P〈0.05 or P〈0.01）.Compared with the normal controls,the level of FT3、FT4、TSH of Graves group has the most significant increase（P〈0.01）,and the level of FT3、FT4 are higher than the normal group and the level of TSH is lower than the normal group.Compared with the normal controls,the level of TSH of HT group is higher than the normal group and has the most significant increase（P〈0.01）.Conclusion It has certain value in diagnosis,differential diagnosis,treatment and prognosis of judge of autoimmune thyroid disease especially in Graves disease and Hashimoto＇s thyroiditis by detecting of thyroid autoantibodies.
出处
《中国实验诊断学》
2018年第2期207-209,共3页
Chinese Journal of Laboratory Diagnosis
