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不同类型甲状腺疾病患者可溶性细胞间黏附分子-1变化及临床意义 被引量：6

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摘要 目的探讨不同类型甲状腺疾病患者可溶性细胞间黏附分子-1(sICAM-1)变化及临床意义。方法选择初诊甲状腺疾病患者137例,其中Graves病(GD)69例(GD组)[伴Graves眼病(GO)20例],桥本甲状腺炎(HT)35例(HT组),单纯性甲状腺肿(SG)20例(SG组),非毒性结节性甲状腺肿(NTNG)13例(NTNG组)。另选健康查体者277例作为对照组。采用125I-sICAM-1 RIA方法检测各组血清sICAM-1,化学发光法检测FT3、FT4、sTSH,放免法检测甲状腺球蛋白抗体(TGAb)、甲状腺微粒体抗体(TMAb),ELISA法检测促甲状腺素受体抗体(TRAb)、甲状腺刺激免疫球蛋白(TSI);采用Spearman等级相关分析,分析sICAM-1与甲状腺功能及甲状腺自身抗体指标的相关性。结果与对照组比较,GD组、HT组sICAM-1明显升高(P均<0.01),GD组与HT组、SG组与NTNG组比较,P均>0.05;GO患者的sICAM-1明显高于非GO患者(P<0.05)。GD组sICAM-1与FT3、FT4呈正相关(r分别为0.467、0.441,P均<0.05),与TRAb、TSI、TGAb、TMAb无明显相关性(P均>0.05)。结论血清sI-CAM-1可作为免疫指标之一,辅助诊断GD、HT等甲状腺疾病。
作者 刘金泉 夏宇靖 李宁 方佩华 冯凭
机构地区 天津医科大学总医院 天津市儿童医院
出处 《山东医药》 CAS 2012年第17期46-48,共3页 Shandong Medical Journal
基金 天津市科技发展计划资助项目(05YFGDSF02700)
关键词 甲状腺疾病 自身免疫性 GRAVES病 细胞间黏附分子-1 放射免疫法
分类号 R581 [医药卫生—内分泌]
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参考文献9

  • 1Kostic I, Toffoletto B, Fontanini E, et al. Influence of iodide excess and interferon-gamma on human primary thyroid cell proliferation, thyroglobulin secretion, and intracellular adhesion molecule-1 and human leukocyte antigen-DR expression [ J ]. Thyroid, 2009, 19 (3) :283-291. 被引量：1
  • 2Rothlein R, Mainolfi EA, Czajkowski M, et al. A form of circulat- ing ICAM-1 in human serum [ J ]. J Immunol, 1991,147 ( 11 ) : 3788-3793. 被引量：1
  • 3Nguyen QM, Srinivasan SR, Xu JH, et al. Distribution and cardio- vascular risk correlates of plasma soluble intercellular adhesion mole- cule-1 levels in asymptomatic young adults from a biracial communi- ty: the Bogalusa Heart Study[J]. Ann Epidemiol, 2010,20( 1 ) : 53-59. 被引量：1
  • 4Ozturk B, Kuscu F, Tutuncu E, et al. Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with crimean-congo hemorrhagic fever[ J]. J Clin Virol, 2010,47 (2) :115-119. 被引量：1
  • 5中国甲状腺疾病诊治指南——甲状腺结节[J].中华内科杂志,2008,47(10):867-868. 被引量：296
  • 6Asnis GM, De La Garza R. Interferon-induced depression in chronic hepatitis C: a review of its prevalence, risk factors, biology, and treatment approaches [ J ]. J Clin Gastroenterol, 2006,40 (4) : 322- 335. 被引量：1
  • 7Ozata M, Bolu E, Sengul A, et al. Soluble intercellular adhesion molecule-1 concentrations in patients with subacute thyroiditis and in patients with Graves' disease with or without ophthalmopathy [ J ]. Endocfind J, 1996,43(5) :517-525. 被引量：1
  • 8Bossowski A, Urban M, Citko A, et al. Serum levels of adhesion molecules (sICAM-1, sVCAM-1 and sP-selectin ) in children and adolescents with thyroid diseases [ J ]. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw, 2000,6 (2) : 79-92. 被引量：1
  • 9Massart C, Sonnet E, Gibassier J, et al. Clinical validity of inter- cellular adhesion molecule-1 ( ICAM-1 ) and TSH receptor antibodies in sera from patients with Graves' disease[J]. Clin Chim Acta, 1997,265 (2) : 157-168. 被引量：1

二级参考文献6

  • 1Gharib H, Papini E. Thyroid nodules: clinical importance, assessment, and treatment. Endocrinol Metab Clin North Am, 2007, 36:707-735. 被引量：1
  • 2AACE/AME Task Force Thyroid Nodules. American Association of Clinical Endocrinologists and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nedules. Endocr Pract, 2006,12:63-102. 被引量：1
  • 3Filetti S, Durante C, Torlontano M. Nonsurgical approaches to the management of thyroid nodules. Nat Clin Praet Endoerinol Metab, 2006, 2:384-394. 被引量：1
  • 4Abalovich M, Amino N, Barbour LA, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab, 2007, 92 :S1-47. 被引量：1
  • 5Cooper DS, Doherty GM, Haugen BR, et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid, 2006, 16: 109-142. 被引量：1
  • 6连小兰.甲状腺结节.见:白耀,主编.甲状腺病学[M].北京:科学技术文献出版社,2004.335-336. 被引量：3

共引文献295

同被引文献33

  • 1李玉姝,陈蕾,滕卫平,单忠艳,李忠民.Effect of immunoglobulin G from patients with Graves’ophthalmopathy and interferon gamma in intercellular adhesion molecule- 1 and human leucocyte antigen- DR expression in human retroocular fibroblasts[J].Chinese Medical Journal,2000(8):80-83. 被引量：2
  • 2中国甲状腺疾病诊治指南——甲状腺功能亢进症[J].中华内科杂志,2007,46(10):876-882. 被引量：856
  • 3吴妙琼,刘艳虹,谭晓军,等.妊娠早期单纯性甲状腺自身抗体阳性与不良妊娠的关系[J].广东医学,2013,34(11):1718-1780. 被引量：9
  • 4Arao T, Morimoto I, Kakinuma A, et al. Thyrocyte proliferation by cellular adhesion to infiltrating lymphocytes through the inter- cellular adhesion molecule-I/lymphocyte function-associated anti- gen-1 pathway in Graves' disease [ J 1. J Clin Endocrinol Metab, 2000,85 ( 1 ) :382-389. 被引量：1
  • 5Wu W, Thomas KA. Pituitary microadenoma: MR appearance and correlation with CT[ J]. Acta Radinlogica, 1995,36 (5) :529-35. 被引量：1
  • 6Ahmadi H, Lars son EM, Jin kins JR. Normal pituitary gland : co- ronal MR imaging of infundibular tilt [ J 1- Radiology, 1990,177 (2) :389-392. 被引量：1
  • 7Kretowski A, Wawmsiewicz N, Mironczuk K, et al. Intercellular adhesion molecule 1 gene polymorphisms in Graves' disease[ J]. J Clin Endocrinol Metab ,2003,88 ( 10 ) :4945-4949. 被引量：1
  • 8Bossowski A,Urban M, Citko A, et al. Serum levels of adhesion molecules ( sICAM-1, sVCAM-1 and sP-selectin ) in children and adolescents with thyroid diseases [ J ]. Endokrynol Diabetol Char Przemiany Materli Wieku Rozw,2000,6(2) :79-92. 被引量：1
  • 9Shimada Y, Hasegawa M, Takehara K, et al. Elevated serum L- selectin levels and decreased L-selectin on CD8 ( + ) lymphocytes expression in systemic sclerosis[ J 1. Clin Exp Immunal,2001,124 (3) :474479. 被引量：1
  • 10Wenisch C, Myskiw D, Gessl A, et al. Circulating selectins, in- tercellular adhesion molecule-1, and vascular cell adhesionmole- cule-1 in hyperthyroidism[ J ]. J Clin Endocrinol Metab, 1995,80 (7) : 2122-2126. 被引量：1

引证文献6

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山东医药
2012年 第17期

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