摘要
目的:基于数据挖掘方法探索岳仁宋教授治疗甲状腺结节的用药规律及特色,总结其临床经验及学术思想。方法:收集整理岳仁宋教授治疗甲状腺结节的处方以建立处方、药物数据库。采用Microsoft Excel 2010软件进行中药频次、功效、性味及归经统计;使用IBM SPSS Modeler 18.0软件中的Apriori算法进行关联规则分析;通过IBM SPSS Statistics 23.0进行聚类分析。结果:纳入的99首处方中,最常用的药物为甘草、柴胡、法半夏、大枣、黄芩、党参;药性多为温、平、寒,药味以甘、辛、苦居多,归经以肺、脾、肝为主;关联规则结果多集中于小柴胡汤、逍遥散及消瘰丸;系统聚类分析归为12类。结论:岳仁宋教授治疗甲状腺结节扶正与祛邪兼施,注重肺、脾胃、肝功能的调节,形成正虚为本,早期气滞痰火郁结,中后期痰瘀互结兼脾肾亏虚的独特辨治思想,并针对气滞、郁火、痰浊、瘀血、热毒、气虚、肾虚等不同病理因素灵活化裁相应的药物组合,确立行气解郁、清肝化痰、清热解毒、涤痰祛瘀、化痰活血补肾等治疗法则,其组方用药体系集中体现了辨证论治的基本原则。
Objective:To summarize Professor Yue Rensong’s clinical experience and clinical thought in the treatment of thyroid nodules,we elucidated the law of drug use for thyroid nodules based on data mining approaches.Methods:The database was established on the basis of the collected prescriptions for thyroid nodules of Professor Yue Rensong.Microsoft Excel 2010 was used for the statistics of frequency,efficacy,property,taste and meridian entries.The Apriori algorithm in IBM SPSS Modeler 18.0 software was utilized for association rule analysis.Cluster analysis was performed by IBM SPSS Statistics 23.0.Results:Among the 99 prescriptions obtained,the most commonly used drugs were Glycyrrhrzae Radix et Rhizoma,Radix Bupleuri,Pinelliae Rhizoma,Jujubae fructus,Scutellariae radix,and Codonopsis radix.The top three properties were warm,neutral and cold.The top three tastes are sweet,pungent and bitter.The main meridian entries were lung,spleen and liver.Most of the association rules were derived from Xiaochaihu Decorction,Xiaoyao Powder and Xiaoluo Pill.16 clustering results were obtained by cluster analysis.Conclusion:Professor Yue Rensong adhered to principle of reinforcement and elimination in combination and paid attention to the function regulation of lung,spleen-atomach and liver in the treatment of thyroid nodules.The unique differentiation and treatment thought,namely,stagnation of qi,phlegm and fire in the early stage,stagnation of phlegm and blood stasis and deficiency of spleen and kidney in the middle and late stages on the basis of the deficiency of positive qi was formed.According to different pathological factors such as qi stagnation,stagnation fire,phlegm turbidity,blood stasis,heat toxicity,qi deficiency and kidney deficiency,the corresponding drug combinations were flexibly prescribed.The treatment principles such as activating qi and relieving depression,clearing liver and dissipating phlegm,clearing away heat and detoxification,eliminating phlegm and removing blood stasis,resolving phlegm,promoting blood
作者
张会择
彭杨梅
岳仁宋
Zhang Huize;Peng Yangmei;Yue Rensong(Affiliated Hospital of Chengdu University of TCM,Chengdu 610072,China)
出处
《亚太传统医药》
2021年第11期182-186,共5页
Asia-Pacific Traditional Medicine
关键词
甲状腺结节
用药规律
数据挖掘
岳仁宋
Thyroid Nodules
Medication Rules
Data Mining
Yue Rensong
