摘要
目的探讨外周血血小板/淋巴细胞比值（platelet-to-lymphocyte ratio, PLR）与大动脉粥样硬化性卒中（large artery atherosclerosis, LAA）及其严重程度的相关性。方法回顾性纳入住院的急性缺血性卒中患者，根据TOAST病因学分型标准分为LAA和非LAA（包括心源性栓塞、小血管闭塞、其他明确病因和病因未明确），根据美国国立卫生研究院卒中量表将LAA进一步分为轻度卒中组（〈8分）和中重度卒中组（≥8分）。比较临床资料、实验室检查指标和PLR，采用多变量logistic回归分析确定LAA及其严重程度的独立危险因素。结果共纳入676例急性缺血性卒中患者。LAA 391例，其中轻度卒中224例，中重度卒中167例；非LAA 285例，其中心源性栓塞94例、小血管闭塞137例、其他明确病因18例和病因未明确36例。LAA组PLR显著高于非LAA组[（172.24±70.45）对（148.37±45.84）；t＝5.001，P〈0.001]。多变量logistic回归分析显示，PLR（优势比1.012，95%可信区间1.004～1.021；P＝0.006）是LAA的独立危险因素。轻度LAA组PLR[（149.74±47.68）对（202.42±83.70）；t＝7.864，P〈0.001]显著低于中重度LAA组。多变量logistic回归分析显示，PLR（优势比1.025，95%可信区间1.008～1.042；P＝0.003）是LAA严重程度的独立危险因素。结论PLR与LAA及其严重程度有关。
Objective To investigate the correlations of peripheral blood platelet-to-lymphocyte ratio （PLR） with large atherosclerotic （LAA） stroke and its severity.Methods Inpatients with acute ischemic stroke admitted to hospital were enrolled retrospectively. They were divided into LAA and non-LAA （including cardioembolism, small vessel occlusion, other undetermined etiology, and undetermined etiology） according to the TOAST classification. LAA was further divided into a mild stroke group （score 〈8） and a moderate to severe stroke group （score ≥8） according to the National Institutes of Health Stroke Scale. The general clinical data, laboratory measurements, and PLR were compared. Multivariate logistic regression analysis was used to identify the independent risk factors for LAA and its severity.
Results A total of 676 patients with acute ischemic stroke were enrolled, including 391 patients with LAA, 224 of them with mild stroke and 167 with moderate to severe stroke; 285 with non-LAA, including 94 cardiogenic embolism, 137 small vessel occlusion, 18 other undetermined etiology and 36 undetermined etiology. PLR in the LAA group was significantly higher than that in the non-LAA group （172.24±70.45 vs. 148.37±45.84; t=5.001, P〈0.001）. Multivariate logistic regression analysis showed that PLR （odds ratio 1.012, 95%confidence interval 1.004-1.021; P=0.006） was an independent risk factor for LAA. PLR in the mild LAA group was significantly lower than that in the moderate to severe LAA group （149.74±47.68 vs. 202.42±83.70; t=7.864, P〈0.001）. Multivariate logistic regression analysis showed that PLR （odds ratio 1.025, 95% confidence interval 1.008-1.042; P=0.003） was an independent risk factor for the severity of LAA.
Conclusions PLR is associated with LAA and its severity.
作者
董琪
夏晓爽
李新
Dong Qi;Xia Xiaoshuang;Li Xin(Department of Neurology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China)
出处
《国际脑血管病杂志》
2017年第11期984-989,共6页
International Journal of Cerebrovascular Diseases
基金
天津市自然科学基金（16JCYBJC25500）
天津市卫生计生委攻关课题（15KG136）
