摘要
目的 检测婴儿特应性皮炎（AD）患者血清维生素D水平,了解血清维生素D与婴儿AD严重程度之间的关系。方法 2016年2 - 4月在山西省儿童医院采用问卷调查方式采集中重度AD组基本信息，参考SCORAD评分法评估疾病严重程度。酶联免疫吸附试验检测AD组和对照组（95例健康体检者）血清25-羟基维生素D3水平以及AD组血清总IgE水平，血细胞分析仪检测AD组血嗜酸性粒细胞比例。结果 97例AD患儿完成研究，中度43例（44.3 %），重度54例（55.7%）。AD组血清25-羟基维生素D3水平［（66.71 ± 21.07） nmol/L］低于健康对照组［（85.43 ± 14.87） nmol/L，P 〈 0.01）］，重度组［（47.54 ± 29.36） nmol/L］低于中度组［（63.89 ± 26.67） nmol/L，P = 0.006］。重度AD组嗜酸性粒细胞比例（0.124 ± 0.094）高于中度组（0.061 ± 0.060）（P 〈 0.001）。中度AD组与重度AD组血清总IgE水平差异无统计学意义（P = 0.375）。AD患者血清25-羟基维生素D3水平与嗜酸性粒细胞比例呈负相关（r = -0.336，P 〈 0.05），但与血清总IgE水平之间无相关性（r = -0.174，P＞0.05）。母乳喂养、补充维生素D与25-羟基维生素D3水平显著相关（P 〈 0.05），而年龄、性别、AD病程、急性期渗出与25-羟基维生素D3水平无显著相关性（均P＞0.05）。结论 婴儿期AD患者血清25-羟基维生素D3水平明显下降，维生素D缺乏与婴儿期AD的严重程度密切相关。
Objective To detect the serum level of vitamin D in infants with atopic dermatitis（AD）, and to investigate the relationship between the serum level of vitamin D and severity of AD in infants. Methods Clinical data were collected from patients with moderate to severe AD （AD group） through a questionnaire survey in Children′s Hospital of Shanxi from February to April in 2016, and the severity of AD was evaluated by the SCORing atopic dermatitis （SCORAD） score. A total of 95 health checkup examinees served as the control group. Enzyme-linked immunosorbent assay（ELISA）was performed to detect the serum level of 25（OH）D3 in the AD group and control group, as well as the total serum IgE level in the AD group. Blood cell analyzer was used to determine the proportion of blood eosinophils in the AD group. Results A total of 97 patients with AD were enrolled into the study, including 43 （44.3 %） patients with moderate AD and 54 （55.7%） patients with severe AD. The serum level of 25（OH）D3 was significantly lower in the AD group than in the healthy control group （[66.71 ± 21.07] nmol/L vs.[85.43 ± 14.87] nmol/L, P 〈 0.01）, as well as in the patients with severe AD than in the patients with moderate AD （[47.54 ± 29.36] nmol/L vs.[63.89 ± 26.67] nmol/L, P = 0.006）. The proportion of blood eosinophils was significantly higher in the severe AD group than in the moderate AD group （0.124 ± 0.094 vs. 0.061 ± 0.060, P 〈 0.001）. There was no significant difference in the total serum IgE level between the moderate AD group and severe AD group （P = 0.375）. Among the patients with AD, the serum level of 25（OH）D3 was negatively correlated with the proportion of blood eosinophils （r =-0.336, P 〈 0.05）, but there was no correlation between the serum level of 25（OH）D3 and total serum IgE level （r = -0.174, P 〉 0.05）. The serum level of 25（OH）D3 was significantly associated with breastfeeding and vitamin D supplementation （P 〈 0.05）, but unrelated to age
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2017年第11期825-828,共4页
Chinese Journal of Dermatology
