摘要
目的:探讨外周血血小板与淋巴细胞比值(platelet to lymphocyte ratio,PLR)与颈动脉粥样硬化斑块炎性反应程度的相关性。方法:入选42例颈动脉动脉粥样硬化斑块的患者。均行正电子发射断层显像(PET/CT),计算颈动脉斑块局部反射性活度标准化靶-本底比(TBR)。根据TBR值将纳入患者分为炎性组(TBR≤1.25)及非炎性组(TBR>1.25)。记录患者血脂、血糖、血压等传统的心脑血管疾病危险因素指标,并记录淋巴细胞计数、血小板计数,计算PLR(血小板计数/淋巴细胞计数)等血液常规检查指标。T检验分析组间差异,Pearson相关性分析方法分析TBR与一般临床资料及PLR的相关关系,多重线性逐步回归方程分析PLR与TBR的独立相关关系。结果:炎性组与非炎性组相比,PLR值明显升高(P=0.011)。Pearson相关分析显示TBR值与年龄(r=0.364,P=0.049)、体质量指数(r=0.38,P=0.038)、载脂蛋白B(r=0.392,P=0.032)、PLR(r=0.535,P=0.002)具有有统计学意义的相关性。多元线性回归分析显示,TBR与PLR之间存在的独立的正相关关系(β=0.368,P=0.02)。结论:PLR在炎性反应较重的颈动脉粥样硬化斑块患者中升高,与其炎性反应程度呈现独立的正相关关系。
Objective： To investigate the correlation between neutrophil to Lymphocyte Ratio（PLR）of Peripheral Blood and the degree of inflammation in carotid atherosclerotic plaques. Methods： 42 patients with carotid atherosclerosis were involved. Using positron emission tomography（PET） to get local reflex activity standardization target to background ratio（TBR） and quantify the inflammatory reaction degree of carotid atherosclerotic plaques. Association between TBR and traditional cardiovascular risk factors,PLR were analyzed by Pearson＇s correlation analysis and multiple linear regression analysis. Results： Pearson correlation analysis showed that TBR was significantly correlated with age, BMI, Apo B and PLR. After adjusting some influencing risk factors, multiple linear regression analysis showed that PLR was independently correlated with TBR. Conclusions： PLR was independently associated with the inflammatory reaction degree of carotid atherosclerotic plaque.
出处
《现代生物医学进展》
CAS
2015年第16期3082-3086,3175,共6页
Progress in Modern Biomedicine
基金
全军医药卫生科研基金项目(11BJZ19)
