摘要
目的采用贝叶斯网状Meta分析的方法评价青霉素皮试前7种不同皮肤处理方法对皮试结果的影响。方法检索PubMed、Cochrane Library、Webof Science、EBSCO、中国生物医学文献数据库、中国知网及万方数据库等中外文数据库，检索时间为建库至2017年7月，纳入对比不同皮肤处理方法对青霉素皮试结果影响的对照试验。采用Cochrane系统评价手册5．1．0版提供的偏倚风险评估工具对纳入研究进行质量评价。2名研究者独立进行数据提取和质量评价，采用WinBUGS、R、Stata软件进行数据处理。结果最终纳人18个研究，共包含25077例患者。网状Meta分析结果表明，0．5％戊二醛、含碘消毒剂、0．9％氯化钠对比常规乙醇消毒皮肤在假阳性率方面的差异有统计学意义（P〈0．05）；此外，其他皮肤处理方式的相互比较差异均无统计学意义（P〉0．05）。基于WinBugs的rank排序结果，排名前4位的依次是0．9％氯化钠、直接注射、0．5％戊二醛、含碘消毒液。结论与常规乙醇消毒相比，0．9％氯化钠清洁、0．5％戊二醛和含碘消毒液消毒均可降低青霉素皮试的假阳性率。
Objective To evaluate the effects of seven different skin interventions in the result of penicillin skin test by network Meta-analysis. Methods A systematic search of PubMed, Cochrane Library, Web of Science, EBSCO, Chinese Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang Database from construction to July 2017 was carried out. Control trials examining the effects of skin interventions on the false positive rate of penicillin skin test were included. Methodological quality of included studies was assessed according to the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0. All data was screened, extracted and reviewed by 2 researchers independently and analyzed by WinBUGS, R and Stata. Results Totally 18 trials involving 25 077 patients were included. The results of network Meta-analysis showed the statistically significant difference in favor of saline, 0.5% glutaral and iodine-containing disinfector when compared to alcohol （P 〈 0.05）. However, there was no difference in effects between other different skin interventions on the false positive rate （P〉0.05）. Probability ranking showed that there was a great possibility for saline, direct injection, 0.5% glutaral and iodine-containing disinfector in the reduction of false positive rate. Conclusions Saline, 0.5% glutaral and iodine-containing disinfector were superior to other skin interventions in reducing false positive rate of penicillin skin test.
出处
《中国实用护理杂志》
2018年第4期315-320,共6页
Chinese Journal of Practical Nursing
关键词
青霉素
皮内注射
消毒剂
网状Meta分析
Penicillin
Intradermal Injection
Disinfector
Network Meta-analysis
