摘要
目的分析食管癌患者放疗期间进行肠内营养治疗对改善患者营养状况的作用。方法以"食管癌""放射治疗""肠内营养"等为关键词,检索万方数据、中国期刊网、维普网等中文数据库;以"esophageal cancer""chemoradiotherapy""enteral nutrition"等为关键词,检索Pub Med、Medline、Cochrane Library等英文数据库,查找关于中国食管癌放疗患者接受肠内营养治疗的随机对照试验,文献发表时间范围为2007年8月—2016年8月。采用Rev Man 5.1软件进行统计分析,运用Meta分析方法计算合并均数差(MD)。结果共检索到26篇文献,最终纳入7个独立的随机对照试验,包括503例患者。Meta分析结果显示,与常规饮食比较,肠内营养治疗可提高食管癌患者体重(MD=5.54,95%CI:3.61~7.46)、BMI(MD=2.20,95%CI:2.02~2.39)、血红蛋白水平(MD=12.46,95%CI:5.86~19.05)、血清白蛋白水平(MD=4.04,95%CI:2.48~5.61)和血清前白蛋白水平(MD=49.53,95%CI:20.93~78.13)。漏斗图表明各项指标未有显著性发表偏倚。结论与常规饮食比较,肠内营养治疗能够改善食管癌放疗患者的营养状况。
Objective To evaluate enteral nutrition treatment on nutritional status of patients with esophageal cancer duringradiotherapy in Chinese population. Methods We searched domestic and foreign relevant databases（PubMed, Medline,Cochrane Library,Wanfang Data,Chinese Journal Database,VMIS ） by key words（esophageal cancer,chemoradiotherapy,enteral nutrition）,meeting the conditions of the clinical randomized controlled trials, and evaluated the quality of eachdocument. We used meta-analysis method to analysis the published literatures about clinical randomized controlled trials,whichwere enteral nutrition treatment on nutritional status of patients with esophageal cancer during radiotherapy in Chinesepopulation.RevMan5.1 statistical analysis software were used. Results Seven separate clinical randomized controlled trialsincluding 503 cases were included into the meta-analysis. The following five indexes of nutritional status in enteral nutritiontreatment （ENT ） group were superior to routine treatment（RT ） group （P〈0.05）：body weight,Body Mass Index（BMI ）,hemoglobin,serum albumin,serum prealbumin. The MD Values and 95%CI（confidence interval ） were 5.54（3.61-7.46 ）,2.20 （2.02-2.39 ）,12.46 （5.86-19.05）,4.04 （2.48-5.61）,49.53（20.93-78.13） .The funnel plot showed no significantpublication bias in each indexes. Conclusion Enteral nutrition treatment can improve the nutritional status of patients withesophageal cancer during radiotherapy compare only with routine treatment.
作者
邱恩毅
赵喜越
金璋
林权冰
QIU En-yi;ZHAO Xi-yue;JIN Zhang;LIN Quan-bing(Wenzhou Central Hospital,Wenzhou,Zhejiang 325000,Chin)
出处
《预防医学》
2018年第2期153-157,共5页
CHINA PREVENTIVE MEDICINE JOURNAL
基金
温州市科技局课题(Y20150216)
关键词
食管癌
肠内营养
放疗
营养状况
META分析
Esophageal cancer
Enteral nutrition
Radiotherapy
Nutritional status
Meta analysis.
