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门冬氨酸鸟氨酸联合前列地尔治疗重度慢性乙型肝炎疗效及对患者血清肿瘤坏死因子-α的影响 被引量:5

Effects of ornithine aspartate combined with alprostadil in the treatment of severe chronic hepatitis B and its effect on serum tumor necrosis factor- α
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摘要 目的 探究门冬氨酸鸟氨酸联合前列地尔治疗重度慢性乙型肝炎疗效及肿瘤坏死因子-α(TNF-α)的影响.方法 选择80例重度慢性乙型肝炎患者;采用随机数字表法分为两组,分别为观察组与对照组,各40例患者.给予对照组患者休息、异甘草酸镁、谷胱甘肽、血浆、白蛋白、抗乙肝病毒等常规治疗,观察组患者在此基础上加用门冬氨酸鸟氨酸联合前列地尔治疗.连续治疗4周后进行疗效观察,并比较治疗前后肝功能变化,采用酶联免疫吸附试验(ELISA)检测血浆TNF-α水平,并详细记录治疗期间不良反应发生情况.结果 观察组治疗总有效率为92.50%,显著高于对照组(80.00%),差异有统计学意义(x^2=6.588,P<0.05);两组治疗前后丙氨酸氨基转移酶(ALT)、凝血酶原活动度(PTA)、总胆红素(TBIL)差异均有统计学意义,其治疗后观察组与对照组差异有统计学意义[(86.56±38.67) U/L比(121.23±39.65) U/L,(62.45±5.46)%比(54.88 ±5.37)%,(175.67 ±42.34) μmol/L比(214.56±43.45)μmol/L,t=3.959、6.252、4.054,均P<0.001];两组治疗前血浆TNF-α水平差异无统计学意义(P>0.05),治疗后两组均显著降低,且观察组显著低于对照组[(176.45±20.41) ng/L比(221.43±21.43) ng/L],差异有统计学意义(t=9.613,P<0.001);观察组不良反应发生率为12.50%,与对照组(10.00%)差异无统计学意义(x^2=0.313,P>0.05).结论 在常规治疗基础上采用门冬氨酸鸟氨酸联合前列地尔治疗重度慢性乙型肝炎能显著提高临床疗效,肝功能明显改善,降低血浆TNF-α水平,且未增加不良反应. Objective To investigate the effect of ornithine aspartate combined with alprostadil in the treatment of severe chronic hepatitis B (CHB),and its effect on serum tumor necrosis factor-α (TNF-α).Methods 80 patients with severe CHB were selected.The patients were divided into the observation group and the control group by digital random method,40 patients in each group.The control group was given conventional treatment of rest,isoglycyrrhizinate magnesium needle,glutathione needle,plasma,albumin,anti-hepatitis B virus.The observation group received ornithine aspartate combined with alprostadil treatment based on the treatment of the control group.After a continuous treatment of 4 weeks,the curative effect was observed,the changes of liver function before and after treatment was compared.Enzyme-linked immunosorbent assay (ELISA) was used to detect the plasma TNF-α level,and the adverse reactions during treatment were recorded.Results The total effective rate of the observation group was 92.50%,which was significantly higher than 80.00% of the control group (x^2 =26.588,P 〈 0.05).The preoperative and postoperative alanine aminotransferase(ALT),prothrombin activity(PTA),total bilirubin (TBIL) of the two groups had statistically significant differences (all P 〈 0.05),and,there were statistically significant differences between the observation group and the control group after treatment[(86.56 ± 38.67)U/L vs.(121.23 ± 39.65)U/L,(62.45 ±5.46)% vs.(54.88 ±5.37) % and (175.67 ±42.34) μmol/L vs.(214.56 ±43.45) μmol/L,t =3.959,6.252,4.054,all P 〈 0.001].The plasma TNF-αt level had no statistically significant difference between the two groups before treatment (P 〉 0.05).After treatment,the TNF-α level of the two groups was significantly decreased,which of the observation group was significantly lower than that of the control group[(176.45 ± 20.41)ng/L vs.(221.43 ± 21.43)ng/L,t =9.613,P 〈 0.001].The incidence rate of adverse reactions
作者 窦永青
出处 《中国基层医药》 CAS 2017年第23期3521-3525,共5页 Chinese Journal of Primary Medicine and Pharmacy
基金 山西省卫生厅科研课题(20130011087)
关键词 肝炎 乙型 慢性 门冬氨酸鸟氨酸 前列地尔 肿瘤坏死因子-Α Hepatitis B,chronic Ornithine aspartate Alprostadil Tumor necrosis factor alpha
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