摘要
目的探讨对肝衰竭患者采用胸腺肽α1联合腺苷蛋氨酸治疗的效果。方法随机选取2019年9月—2021年9月期间福建医科大学孟超肝胆医院接收的肝衰竭患者100例作为研究对象。根据随机数表法分为两组,给予腺苷蛋氨酸治疗的50例作为对照组,给予胸腺肽α1联合腺苷蛋氨酸治疗的50例作为观察组。比较两组临床疗效总有效率、肝功能指标(总胆红素、谷丙转氨酶、血白蛋白)水平、凝血功能指标(凝血酶原时间、血浆凝血酶原活动度、活化部分凝血活酶时间和D-二聚体)水平。结果观察组治疗6周后临床总有效率(94.00%)高于对照组(80.00%),差异有统计学意义(χ^(2)=4.332,P<0.05)。观察组血清总胆红素、谷丙转氨酶水平均低于对照组,血清白蛋白水平高于对照组,差异有统计学意义(P<0.05)。观察组凝血酶原时间、活化部分凝血活酶时间均短于对照组,差异有统计学意义(P<0.05)。观察组D-二聚体水平低于对照组,差异有统计学意义(P<0.05)。观察组凝血酶原活动度高于对照组,差异有统计学意义(P<0.05)。结论胸腺肽α1联合腺苷蛋氨酸治疗肝衰竭疗效较好,可改善血清总胆红素、谷丙转氨酶及白蛋白水平,值得临床应用。
Objective To investigate the effect of thymosinα1 combined with adenosylmethionine in the treatment of patients with liver failure.Methods A total of one hundred patients with liver failure were randomly selected from Mengchao Hepatobiliary Hospital of Fujian Medical University from September 2019 to September 2021.They were divided into two groups according to numerical randomization.Fifty patients treated with adenosylmethionine were the control group,and fifty patients treated with thymosinα1 combined with adenosylmethionine were the observation group.The total effective rate,liver function indexes(total bilirubin,alanine aminotransferase,blood albumin)levels,and coagulation function indexes(prothrombin time,plasma prothrombin activity,activated partial thromboplastin time and D-dimer)of the two groups were compared.Results After 6 weeks of treatment,the total clinical effective rate of the observation group(94.00%)was higher than that of the control group(80.00%),and the difference was statistically significant(χ^(2)=4.332,P<0.05).The levels of serum total bilirubin and alanine aminotransferase in observation group were lower than those in control group,and the serum albumin level was higher than that in control group,the difference was statistically significant(P<0.05).The prothrombin time and activated partial thrombin time in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).The level of D-dimer in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).The prothrombin activity in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Thymosinα1 combined with adenosylmethionine is effective in the treatment of liver failure,and can improve serum total bilirubin,alanine aminotransferase and albumin levels,which is worthy of clinical application.
作者
杨世达
YANG Shida(Department of Critical Care Medicine,Mengchao Hepatobiliary Hospital of Fujian Medical University,Fuzhou,Fujian Province,350025 China)
出处
《中外医疗》
2023年第27期5-8,共4页
China & Foreign Medical Treatment
关键词
胸腺肽Α1
腺苷蛋氨酸
肝衰竭
Thymosinα1
Adenosylmethionine
Hepatic failure
