摘要
目的:评价一种新型含亚锡-氟化钠牙膏中亚锡离子的菌斑渗透率和脂多糖(LPS,内毒素)中和效率。方法:采用随机、对照、单盲的原位临床试验。分为PBS、新型亚锡-氟化钠牙膏(EXP)和市售亚锡-氟化钠牙膏(MKD)3组。用荧光染料、荧光探针及激光共聚焦荧光共定位方法分析。结果:EXP组亚锡离子菌斑渗透率和LPS中和效率显著优于MKD和PBS组(P<0.05)。EXP组亚锡离子和结合态LPS的荧光存在96.52%的空间共定位。结论:新型含亚锡-氟化钠牙膏中的亚锡离子能渗入菌斑内部并中和LPS。
Objective： To evaluate the dental biofilm penetration efficiency of a novel stabilized stannous-containing sodium fluoride dentifric （EXP） and its lipopolysaccharide （LPS） neutralization efficiency. Methods： A controlled, randomized, examinerblind in situ clinical trial was conducted with the treatment of PBS（ control）, EXP and a marketed stannous-containing sodium fluoride dentifrice （MKD）. Fluorescent dye, fluorescent probe and fluorescence colocalization were used for sample examination and analysis. Resuits： EXP offered better stannous penetration into the biofilm than MKD and PBS（P 〈 0.05）, as well as greater LPS neutralization efficiency（P 〈0.05）. There was a 96.52% overlap of stannous ions and bounded LPS at the same sites treated by EXP. Conelusion： EXP is more effective than MKD in the delivery of stannous into the biofilm and in the neutralization of LPS.
出处
《实用口腔医学杂志》
CSCD
北大核心
2017年第6期758-762,共5页
Journal of Practical Stomatology
