摘要
目的：观察西吡氯铵含漱液在口腔念珠菌感染方面的治疗效果。方法回顾分析88例念珠菌感染患者，按照所选用治疗药物的不同将88例患者均分至采用西吡氯铵含漱液治疗念珠菌感染的治疗组与采用复方氯己定含漱液的对照组，每组各44例。观察对比并分析两组患者口腔疼痛改善情况、口腔黏膜萎缩情况、牙齿红肿出血情况、镜检阳性率、菌落数情况以及患者口腔的红斑评分、临床疗效和不良反应情况等。结果研究结果显示，治疗组治疗总有效率为95．5％，明显高于对照组的77．3％，差异有统计学意义（χ^2＝8.063，P ＝0．019）；对比两组黏膜萎缩及红斑评分发现，治疗组治疗后黏膜萎缩及红斑评分均明显优于对照组，差异有统计学意义（t ＝6．142，P ＝0．033；t ＝6．554，P ＝0．044）；治疗组治疗后菌落数及镜检阳性率均优于对照组，差异有统计学意义（χ^2＝11．596，P ＝0．019；χ^2＝6．994，P ＝0．031）。结论在口腔念珠菌感染病症中应用西吡氯铵含漱液进行治疗，不仅效果显著，而且能有效减缓患者口腔的疼痛、降低不良反应的发生、安全可靠，值得在口腔念珠菌感染中推广应用。
Objective To observe the treatment effect of cetylpyridinium chloride gargle on the oral candidi-asis infection.Methods According to the selection of different drugs,88 cases with candidiasis infection were divided into the cetylpyridinium chloride gargle treatment group and the compound chlorhexidine gargle control （control group）,44 cases in each group.The oral pain improvement,oral mucosal atrophy,swollen gums bleeding,microscopy positive rate,colony number and patients with oral erythema score,clinical efficacy and adverse reactions were observed and compared in the two groups.Results The total effective rate of the treatment group was 95.5%,which was significantly higher than 77.3% in the control group（χ^2 =8.063,P =0.019）,and the difference was statistically significant.After treatment,mucosal atrophy and erythema scores of the treatment group were significantly better than control group,and there were statistically significant differences （t =6.142,P =0.033;t =6.554,P =0.044）.After treatment,the number of colonies and microscopic examination positive rate of the treatment group were better than those of the control group,and with statistical significance （χ^2 =11.596,P =0.019;χ^2 =6.994,P =0.031 ）. Conclusion Cetylpyridinium chloride gargle in the treatment of oral candidiasis infection disease not only has signifi-cant effect and can effectively reduce the pain of patients with oral,reduce the incidence of adverse reaction,it is safe and reliable,it is worth popularization and application in oral candidiasis.
出处
《中国基层医药》
CAS
2016年第10期1466-1469,共4页
Chinese Journal of Primary Medicine and Pharmacy
