摘要
编码转录因子的同源异形盒(homeobox,HOX)基因在染色体上串联成簇排列,是生物发育中决定身体节段边界的重要基因.HOX在机体不同部位有相应的表达模式,同时HOX的表达也包含着成体细胞的位置信息.HOX基因在癌症发生发展中起重要作用,在白血病中的研究一直以来都受到关注,近年来HOX在肺癌、胃肠道肿瘤、前列腺癌、乳腺癌和卵巢癌等实体瘤中的研究也成为新的热点.HOX基因的表达调控、细胞学功能和转录活性的研究对阐明HOX在癌症中的作用具有重要意义.
Homeobox（HOX） genes, coding for transcription factors, are located in clusters in chromosomes and are important for defining body segment boundary. HOX genes show specific expression pattern in correspondent body part, and their expressions also represent the location information of an adult cell. HOX genes take important role in cancer initiation and progression. Researches on HOX in leukamia have contituously been concerned, while researches on HOX in solid tumors, including lung cancer, gastrointestinal cancer, breast cancer and prostate cancer gain growing attention recently. It is of great importance to illustrate HOX expression regulation, cellular level function and transcriptional activity regulation for clarifying the role of HOX in cancer.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2017年第9期737-750,共14页
Progress In Biochemistry and Biophysics
