摘要
小檗碱(BBR)作为抗肠道感染的经典药已为人们所熟知,其抑制肠道菌的作用是其治疗肠道感染作用的核心。随着对肠道菌在肠道的生存变化及其相关代谢产物对全身生理病理功能所产生影响的不断认知,越来越多的文献显示BBR可能通过影响肠道菌从而对体内糖脂代谢以及脑功能活动产生影响。本文在此背景下对BBR抑菌作用的研究进行分析综述,并依据原核生物基因表达的特点对BBR可能作用的分子靶点进行分析,以期有助于对BBR调控肠道菌机制的深入研究,从而更全面的认识BBR的药理作用。
Berberine （BBR） is known as a classic drug for intestinal infection treatment. BBR inhibits intestinal bacteria,which is the core of its role in the treatment of intestinal infection. With the survival of local intestinal bacteria and its related metabolites on the physiological and pathological functions of the body continue to recognize the impact of it, more and more literatures have presented the effect of BBR through the impact of intestinal bacteria on the body glycol- lipid metabolism, even brain function. This allows us to re-understand the pathophysiology of BBR in inhibiting gut microbiome. In this paper, the antibacterial activity of BBR was reviewed and analyzed. The possible molecular target of BBR was analyzed according to the characteristics of prokaryotes gene expression, which was helpful to the in-depth study of BBR on intestinal bacteria. Thus, a more comprehensive understanding of the pharmacological effects of BBR is given.
作者
李慧玉
袁梽漪
王玉刚
雷帆
邢东明
谢伟东
李俊
杜力军
Li Huiyu Yuan Zhiyi Wang Yugang Lei Fan Xing Dongming Xie Weidong Li Jun Du Lijun(Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China College of Pharmacy, Chongqing Medical University, Chongqing 400016, China School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China Division of Life Science ＆ Health, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518005, China State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Chinese Medicine, Nancang 330006, China)
出处
《世界科学技术-中医药现代化》
CSCD
2017年第4期596-601,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委重大研究计划培育项目(项目编号90713043):基于BBR神经元保护作用探讨其PI3-K/AKT作用的始动位点及其信号转导
负责人:杜力军
国家自然科学基金委面上项目(项目编号:81374006):基于BBR作为DNA插入子探讨其对正常与缺血再灌神经元基因转录作用差异的机制
负责人:邢东明
关键词
小檗碱
肠道
微生物
基因转录
Berberine, gut, microbiota, gene transcription
