摘要
目的探讨薄芝糖肽联合血塞通和水蛭颗粒对改善眩晕患者血流变学以及椎动脉血流动力学的影响。方法选取2016年1月～2016年5月张家口市崇礼县中医院收治的眩晕患者110例，根据治疗方案的不同分为实验组（n=55）和对照组（n=55）。实验组采用静脉滴注薄芝糖肽和血塞通，同时口服水蛭颗粒治疗。对照组采用常规西医和口服中药汤剂进行治疗。比较两组治疗前后血液流变学指标及椎动脉血流动力学指标，并统计疗效和不良反应。结果治疗后两组全血高／低切黏度、血浆黏度、红细胞压积和纤维蛋白原均有所降低（P〈0．05或P〈0．01），实验组全血高／低切黏度、血浆黏度和红细胞压积低于对照组（P〈0．05或P〈0．01）。两组左椎动脉、右椎动脉和基底动脉血流速度均较治疗前有所升高（P〈0．05或P〈0．01），且实验组显著高于对照组（P〈0．05或P〈0．01）。治疗后实验组治疗总有效率（92．73％）与对照组（87．27％）无显著差异（P〉0．05）；实验组不良反应发生率（7．27％）明显低于对照组（27．27％）（P〈0．01）。结论薄芝糖肽联合血塞通以及口服水蛭颗粒治疗眩晕，改善了患者的血液流变学和椎动脉血流动力学，疗效确切，副作用少，值得临床推广。
Objective To investigate the clinical efficacy of Bozhi glycopeptides combined with Xuesaitong and leech gran- ules on hemorheology and vertegbral artery hemodynamics in vertigopatients. Methods 110 Patients with vertigo from January to May in 2016 in our hospital were selected and randomly divided into the experiment group （ n = 55 ） and the control group （ n = 55 ） according to the different treatment options. The experiment group received Bozhi glycopeptides combined with Xuesaitong and leech granules. The control group accepted conventional western medicine and decoction of Traditional Chinese Medicine. The changes of hemorheology and vertebral artery hemodynamics were compared between the two groups before and after treatment. The curative effects and adverse reactions in the two groups were observed. Results After treatment the blood high/low shear viscosity, plasma viscosity, hematocrit and fibrinogen in the two groups were decreased （ P 〈 0. 05 or P 〈 0. 01 ）, and the blood high/low shear viscosity, plasma viscosity and hematocrit in the experiment group were significantly lower than those in the control group （ P 〈 0. 05 or P 〈 0. 01 ）. After treatment vertebral artery, right vertebral artery and basilar artery blood flow velocity in the two groups were increased （ P 〈 0. 05 orP 〈0. 01 ）. And the ones in the experiment group were significantly hgher than those in the control group （ P 〈0. 05 orP 〈 0. 01 ）. There was no significant difference in the total effective rate between the experiment group （92.73%） and the control group （87, 27% ） （P 〉0.05）. The incidence of adverse reactions in the experiment group （7. 27% ） was significantly lower than that in the control group （27, 27% ） （ P 〈 0. 01 ）. Conclusion Bozhi glycopeptie combined with Xuesaitong and leech granules can im- prove the hemorheology and vertebral artery hemodynamics of vertigopatients, which has curative effect and less side effects.
出处
《国际老年医学杂志》
2017年第4期172-175,共4页
International Journal of Geriatrics
关键词
眩晕
薄芝糖肽
血塞通
水蛭
血流动力学
Vertigo
Bozhi glycopeptie
Xuesaitong
Leech
Hemodynamics
