摘要
目的探究血管生成素1/血管生成素2比值(Ang-1/Ang-2)与急性肺损伤(ALI)患者预后的关系。方法选取2015年6月—2017年1月栾城人民医院ICU收治的ALI患者44例,根据患者预后分为死亡组18例和存活组26例,另选取同期在本院体检健康者30例作为对照组。比较3组受试者血清血管生成素1(Ang-1)、血管生成素2(Ang-2)、血管内皮生长因子(VEGF)水平及Ang-1/Ang-2,比较死亡组与存活组患者急性生理学与慢性健康状况评价系统Ⅱ(APACHEⅡ)评分;Ang-1/Ang-2与ALI患者血清VEGF水平和APACHEⅡ评分的相关性分析采用Pearson相关性分析。结果存活组和死亡组患者血清Ang-1、Ang-2、VEGF水平高于对照组,Ang-1/Ang-2低于对照组(P<0.05);死亡组患者血清Ang-1、Ang-2、VEGF水平高于存活组,Ang-1/Ang-2低于存活组(P<0.05)。死亡组患者APACHEⅡ评分高于存活组(P<0.05)。Pearson相关性分析结果显示,Ang-1/Ang-2与ALI患者血清VEGF水平及APACHEⅡ评分呈负相关(r值分别为-6.832、-7.125,P<0.001)。结论 Ang-1/Ang-2与ALI患者血管内皮细胞功能及预后有关。
Objective To explore the correlation between angiogenin - 1/angiogenin -2 ratio and prognosis in patients with acute lung injury. Methods From June 2015 to January 2017 , a total of 44 patients with acute lung injury were selected in ICU, the Peopled Hospital of Luancheng, and they were divided into death group （ n = 18 ） and survival group （ n =26） according to the prognosis, meanwhile a total of 30 healthy people admitted to this hospital for physical examination were selected as control group. Serum levels of angiogenin - 1, angiogenin - 2 and VEGF, and angiogenin - 1/angiogenin - 2 ratio were compared among the three groups, APACHE Ⅱ score was compared between death group and survival group; correlations of angiogenin - 1/angiogenin -2 ratio with serum VEGF level and APACHE II score were analyzed by Pearson correlation analysis. Results Serum levels of angiogenin - 1, angiogenin - 2 and VEGF of death group and survival group were statistically significantly higher than those of control group, while angiogenin - 1/angiogenin -2 ratio of death group and survival group was statistically significantly lower than that of control group, respectively （ P 〈 0. 05 ） ; serum levels of angiogenin - 1, angiogenin -2 and VEGF of death group were statistically significantly higher than those of survival group, while angiogenin - 1/angiogenin -2 ratio of death group was statistically significantly lower than that of survival group （P 〈 0. 05 ） . APACHE Ⅱ score of death group was statistically significantly higher than that of survival group （ P 〈 0. 05 ）. Pearson correlation analysis results showed that, angiogenin - 1/angiogenin -2 ratio was negatively correlated with serum VEGF level （ r = -6.832） and APACHE Ⅱ score （r = -7. 125） in patients with acute lung injury, respectively （P 〈0. 001） . Conclusion Angiogenin - 1 /angiogenin - 2 ratio is significantly correlated with the vascular endothelial cell function and prognosi
出处
《实用心脑肺血管病杂志》
2017年第7期41-43,56,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
石家庄市科技局课题(161462723):血管生成素评价急诊科早期感染综合征患者预后的研究
