摘要
目的探讨Ki67和VEGF的表达与大肠癌发生、发展过程中临床病理特征的关系。方法采用回顾性研究的方法,分析354例大肠癌患者肿瘤组织中Ki67和VEGF的表达,并分析其与患者临床病理特征的相关性。结果 354例大肠癌的Ki67表达指数为(57.38±19.64)%;VEGF阳性率为59.60%。不同肿瘤大小、病理分期、浸润深度、有无淋巴结转移、肠外转移的大肠癌患者Ki67和VEGF表达差异均有统计学意义(P均<0.05);不同性别、肿瘤部位患者Ki67和VEGF表达差异无统计学意义(P>0.05)。Ki67和VEGF的异常表达存在一定的相关性(C=0.311,P<0.001)。结论 Ki67和VEGF的异常表达与大肠癌的发生、发展相关。
Objective To investigate the relationship between the expression of Ki67 and VEGF and the clinicopathological features of colorectal cancer.MethodsThe expression of Ki67 and VEGF in 354 colorectal cancer patients was analyzed in an retrospective study,as well as the correlation between their expression and the clinicopathological features of colorectal cancer.ResultsIn the 354 patients,the Ki67 expression index was （57.38±19.64）%,and the VEGF positive rate was 59.60%. The expression of Ki67 and VEGF in colorectal cancer patients was significantly different with different tumor size,pathological stage,depth of invasion,lymph node metastasis and parenteral metastasis（P〈0.05）,but had no significant difference in gender or location （P〉0.05）. The abnormal expression of Ki67 and VEGF had a correlation（P=0.000,C=0.311）.ConclusionThe abnormal expression of Ki67 and VEGF was associated with the development and progression of colorectal cancer.
出处
《宁夏医科大学学报》
2017年第5期515-518,共4页
Journal of Ningxia Medical University
关键词
大肠癌
KI67
VEGF
临床病理
VEGF
colorectal cancer
VEGF
clinicopathological features
