摘要
目的观察中药内服联合铁皮石斛滴眼液治疗白内障术后干眼的临床效果。方法前瞻性随机对照临床研究。2014年8月—2016年2月在北京中医医院顺义医院行白内障超声乳化术后1周经检查确诊为干眼的患者124例(124只眼),根据信封抽签法分为观察组与对照组各62例,对照组单独使用铁皮石斛滴眼液治疗,观察组给予中药内服联合铁皮石斛滴眼液治疗,治疗时间为4周。观察两组患者症状积分、泪膜破裂时间(BUT)、Schirmer I试验(SIT)及泪液中白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)含量的变化情况。结果 1.所有患者都顺利完成治疗,治疗期间无严重不良反应发生。2.症状疗效:观察组62例,显效52例,有效8例,无效2例,有效率96.8%;对照组62例,显效20例,有效30例,无效12例,有效率80.6%,观察组的有效率明显高于对照组(P<0.05)。3.症状积分:治疗前观察组与对照组的症状积分分别为6.47±1.22与6.39±1.65,治疗后为1.91±0.19与2.76±0.25,均较治疗前降低(P<0.05),观察组治疗后的症状积分明显低于对照组(P<0.05)。4.BUT:治疗前观察组与对照组的BUT分别为(4.42±1.67)s与(4.28±1.34)s(P>0.05),治疗后为(9.91±2.19)s与(7.56±1.45)s,均较治疗前增加(P<0.05),观察组BUT值大于对照组(P<0.05)。5.SIT:治疗前观察组与对照组的SIT分别为(5.13±1.48)mm/5 min和(5.19±1.39)mm/5 min(P>0.05),治疗后为(9.74±1.89)mm/5 min和(6.98±1.83)mm/5 min,均较治疗前改善(P<0.05),观察组好于对照组(P<0.05)。6.泪液IL-6和TNF-ɑ含量:治疗前,观察组泪液IL-6含量(1345.3±234.0)pg/ml,TNF-α含量(1156.3±223.1)pg/ml;对照组泪液IL-6(1311.9±189.4)pg/ml,TNF-α(1181.9±189.5)pg/ml,两组水平相当(P>0.05)。治疗后,观察组IL-6(308.4±82.5)pg/ml,TNF-α(265.3±89.1)pg/ml;对照组IL-6(613.9±90.6)pg/ml,TNF-α(456.2±93.1)pg/ml,两组组内及组间差异均有统计学意义(P<0.05),观察组好于对照组。结论中药内服联合铁皮石斛滴眼液治疗�
OBJECTIVE To observe the clinical effects of traditional Chinese medicine combined with dendrobium eye drops on dry eye after cataract surgery. METHODS This trail used a prospective and double-blind scheme. From August 2014 to February 2016, 124 dry eye patients（124 eyes） had been included in Shunyi branch of Beijing hospital of traditional Chinese medicine after cataract surgery. Then they were divided into observation group and control group evenly by draw lots. Patients in control group were managed by dendrobium eye drops while sub-jects in observation group were treated by traditional Chinese medicine combined with dendrobium eye drops. The treatment lasted for 4 weeks and the tear secretion（SIT）, tear break-up time（BUT）, symptom score, the contents of interleukin-6（IL-6） and tumor necrosis factor alpha（TNF-α） in tears were detected and recorded. RESULTS 1.All patients accepted whole treatment course and no serious adverse reactions occurred during the trial. 2. Symp-toms： Among 62 cases in observation group, 52 were markedly effective, 8 effective, 2 ineffective, the responsive ratewas 96.8%; Among 62 cases in control group, 20 were markedly effective, 30 effective, 12 ineffective, the responsive rate was80.6%. The effective rate of observation group was significantlyhigher than the control group（P〈0.05）. 3.Symptom score： Before treatment, the symptom score in the observation group and the control group were 6.47 ±1.22 points and 6.39 ±1.65 points; after treatment, result were 1.91 ±0.19 points and 2.76±0.25 points that were both decreased significantly（P〈0.05）. The symptom score in observation group after treatment was significantly lower than that in control group（P〈0.05）. 4. BUT： The BUT in the treatment group and control group were 4.42±1.67 s and 4.28 ±1.34 s before treatment（P〈0.05） and increased to 9.91 ±2.19 s and7.56±1.45 s after treatment. Both variations in two groups were of statistical difference（P〈0.05） and the result of observat
出处
《中国中医眼科杂志》
2017年第2期111-114,共4页
China Journal of Chinese Ophthalmology
关键词
中药内服
铁皮石斛滴眼液
白内障
干眼
炎症因子
Chinese medicine
dendrobium eye drops
cataract
dry eye
inflammatory factors
