摘要
目的:对注射用丹参多酚酸盐治疗急性脑梗死患者的临床疗效及对患者神经功能的保护作用和ET-1水平的影响进行分析。方法:收集2016年1月—2016年12月急性脑梗死患者100例随机分两组。对照组采用常规神经内科治疗方法,干预组在对照组基础上给予注射用丹参多酚酸盐治疗。比较两组患者急性脑梗死治疗总有效率;药物不良反应发生率;治疗前和治疗后患者全血比黏度、红细胞聚集指数、血浆比黏度、ET-1水平的差异。治疗前和治疗后患者神经功能缺损评分、脑血管储备能力、屏气指数的差异。结果:干预组患者急性脑梗死治疗总有效率96.00%高于对照组76.00%,χ2=4.153,P<0.05。治疗前两组神经功能缺损评分、脑血管储备能力、屏气指数比较无显著差异。干预组分别为26.15±1.01、18.62±3.15、0.81±0.12,对照组分别为26.52±0.91、18.24±3.31、0.82±0.16,P>0.05;治疗后干预组神经功能缺损评分、脑血管储备能力、屏气指数改善幅度更大,干预组分别为10.76±0.51、36.55±5.99、1.45±0.24,对照组分别为15.11±1.24、22.15±5.41、1.01±0.37,P<0.05。干预组药物不良反应发生率和对照组对比,发生率均为8.00%,差异不显著,χ2=0.000,P>0.05。治疗前两组全血比黏度、红细胞聚集指数、血浆比黏度、ET-1水平比较无显著差异,干预组分别为5.72±0.67、11.25±0.71、1.92±0.42、74.01±6.22,对照组分别为5.67±0.61、11.21±0.81、1.94±0.41、74.01±6.21,P>0.05;治疗后干预组全血比黏度、红细胞聚集指数、血浆比黏度、ET-1水平改善幅度更大,干预组分别为4.21±0.51、9.22±0.26、1.53±0.19、61.55±1.59,对照组分别为5.43±0.29、10.45±0.22、1.82±0.34、67.48±4.34,P<0.05。结论:注射用丹参多酚酸盐治疗急性脑梗死患者的临床疗效及对患者神经功能的保护作用和ET-1水平的影响大,可有效改善患者临床症状和神经功能,促进ET-1水平降低,改善患者血液�
Objective：To analyze the clinical curative effect and the protective effect on the neurological function and the level of ET - 1 in patients with acute cerebral infarction treated with Salvia mihiorrhiza. Methods ： One hundred patients with acute cere- bral infarction were enrolled in this study from January 2016 to December 2016. The control group was treated with conventional neurology. The intervention group was treated with Danshen phenolic acid for injection on the control group. The total effective rate of acute cerebral infarction was compared between the two groups and observe the incidence of adverse drug reactions, the ratio of whole blood viscosity, erythrocyte aggregation index, plasma specific viscosity and ET - 1 level before and after treatment. Pregnan- cy and post - treatment patients with neurological deficit score, cerebrovascular reserve capacity, breath - hold differences were an- alyzed. Results ：The total effective rate of acute cerebral infarction was 96.00% in the intervention group and 76.00% in the con- trol group, X2 = 4. 153 ,P 〈 0. 05. There were no significant differences in neurological deficit score, cerebrovascular reserve capac- ity or breath - hold index between the two groups before treatment. They were 26.15 ± 1.01,18.62 ± 3.15 and 0.81± 0.12, re- spectively in the intervention group. The control group＇s were 26.52 ± 0.91, 18. 24 ±3.31 and 0.82 ±0. 16, P 〉 0. 05. After treatment, the neurological deficit score, cerebrovascular reserve capacity and breath - hold index were significantly improved in the intervention group （ 10.76 ± 0.51,36.55 ±5.99,1.45 ± 0.24 vs 15.11 ± 1.24 ,22.15 ± 5.41,1.01 ±0.37, P 〈 0. 05 ）. The incidence of adverse drug reactions in the intervention group was 8.00% and compared with the control group, the difference was not significant, X2 = 0. 000,P 〉 0. 05. There were no significant differences in blood viscosity, erythrocyte aggregation index, plas- ma specific viscosity or ET - 1 level between the two groups before tre
出处
《辽宁中医杂志》
CAS
北大核心
2017年第6期1222-1225,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
四川省科技基金项目(2013120067)
关键词
注射用丹参多酚酸盐
急性脑梗死患者
临床疗效
神经功能
保护作用
ET-1水平
Danshen Polyphenate Injection
acute cerebral infarction
clinical efficacy
neurological function
protective effect
ET - 1 level
