盐酸川芎嗪注射液联合丁苯酞软胶囊治疗急性脑梗死疗效及对患者血液流变学影响被引量：69

Efficacy of ligustrazine hydrochloride injection combined with butylphthalide capsule in the treatment of acute cerebral infarction and the effect of hemorheology

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摘要目的:探讨盐酸川芎嗪注射液联合丁苯酞软胶囊治疗急性脑梗死效果及对血液流变学的影响,为临床诊疗提供依据。方法:选取急性脑梗死患者76例作为研究对象。采用随机数表法,分两组,各38例。对照组采用丁苯酞软胶囊治疗,观察组采用盐酸川芎嗪联合丁苯酞软胶囊治疗。治疗1个疗程后比较治疗效果,记录治疗前、后美国国立卫生研究院卒中量表(NHISS)评分、血液流变学[全血低切黏度(LSV)、全血高切黏度(HSV)、血浆黏度(PSV)、血浆纤维蛋白原(FIB)]、S-100蛋白(S100B)、神经元特异性烯醇化酶(NSE)、血清同型半胱氨酸(Hcy)变化,记录不良反应。结果:观察组的总有效率高于对照组,差异有统计学意义(P<0.05)。观察组NHISS评分低于对照组,血液流变学指标均低于对照组,差异有统计学意义(P<0.05)。治疗后观察组的S100B、Hcy水平低于对照组,而NGF高于对照组,差异有统计学意义(P<0.05)。两组治疗过程中均未出现不良反应。结论:盐酸川芎嗪注射液加丁苯酞软胶囊治疗急性脑梗死效果优于单用丁苯酞软胶囊,可更加有效改善患者血液流变学及神经功能,降低血清Hcy水平,安全性较高。 Objective:To explore the effect of ligustrazine hydrochloride injection combined with butylphthalide capsule in the treatment of acute cerebral infarction and its influence on hemorheology,so as to provide basis for clinical diagnosis and treatment.Methods:76 cases patients with acute cerebral infarction were selected as the research objects,and were randomly divided into two groups each group 38 cases.The control group was treated with butylphthalide capsule,and the observation group was treated with Ligustrazine hydrochloride and butylphthalide capsule.After one courses of treatment,the therapeutic effects were compared,and the scores of NHISS,hemorheology(LSV,HSV,PSV,FIB),S100B,NSE,serum homocysteine were recorded before and after treatment,adverse reactions were recorded.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The NHISS score of the observation group was lower than that of the control group,while the hemorheology index of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).After treatment,S100B and Hcy levels in the observation group were lower than those in the control group,while NGF was higher than that in the control group,the difference was statistically significant(P<0.05).There were no adverse reactions in the two groups.Conclusion:Ligustrazine hydrochloride injection and butylphthalide soft capsule in the treatment of acute cerebral infarction can more effectively improve the hemorheology and nerve function of patients,reduce the level of serum Hcy,with high safety,which is worthy of clinical application.