摘要
目的分析血清淀粉样蛋白A在早期胃癌中的预警、鉴定区别和早期诊断的价值。方法选取2015年1月~2016年12月医院收治50例原发性胃癌患者和50例胃溃疡患者,再选取同期50例健康体检者作为对照组,采用散射速率比浊法检测三组的超敏C反应蛋白(hs-CRP)以及血清淀粉样蛋白A(SAA),再采用电化学发光法检测三组的癌胚抗原(CEA)水平。比较三组各指标之间的差异,并将各指标的差异进行相关性分析。结果胃癌组及胃溃疡组的hs-CPR、SAA水平显著高于对照组(P<0.05),且胃癌组hs-CRP、SAA水平明显高于胃溃疡组;胃癌组CEA水平显著高于胃溃疡组和对照组(P<0.05),且胃溃疡组与对照组在CEA水平方面的差异无统计学意义。浸润深度:50例胃癌患者中,T_1期患者SAA水平显著低于其他期患者(P<0.05),而T_4期患者SAA水平显著高于其他期患者(P<0.05);临床分期:SAA水平随着TNM分期的变化而变化,Ⅰ、Ⅱ期患者的SAA水平显著低于Ⅲ、Ⅳ期患者(P<0.05);淋巴结转移:伴随淋巴结转移的胃癌患者SAA水平显著低于不伴随淋巴结转移的胃癌患者(P<0.05);而hs-CRP、CEA在浸润深度、临床分期以及淋巴结转移方面的差异无统计学意义。结论血清淀粉样蛋白A在早期胃癌的诊断、鉴别以及病理分期中具有重要的作用。
Objective To analyze the value of early warning, differences of identification and early diagnosis of serum amyloid A in early gastric cancer. Methods A total of 50 patients with primary gastric cancer and 50 patients with gas- tric ulcer who were enrolled in the hospital from January 2015 to December 2016 were selected. Then 50 cases of healthy subjects were selected as the control group. High sensitive C-reactive protein（hs-CRP） and serum amyloid A （SAA） were detected by scatter velocity turbidimethy. The levels of carcinoembryonic antigens（CEA） were detected by electrochemiluminescence. The differences of indicators between the three groups were compared, and the correlation analysis was carried out for the differences between the indicators. Results. The levels of hs-CRP and SAA in gastric cancer group and gastric ulcer group were significantly higher than those in the control group（P〈0.05）, and the levels of hs-CRP and SAA in the gastric cancer group were significantly higher than those in the gastric ulcer group; the level of CEA in the gastric cancer group was significantly higher than that in the gastric ulcer group and the control group（P〈0.05）. There was no statistically significant difference in CEA level between the gastric ulcer group and the control group. Depth of infiltration： among 50 patients with gastric cancer, the SAA level at T1 stage patients was significantly lower than those in other patients （P〈0.05）, and the level of SAA in T4 patients was significantly higher than that in other pa- tients（P〈0.05）; clinical staging： the level of SAA was changing according to the change of TNM staging, and the level of SAA in the patients at stage Ⅰ and Ⅱ was significantly lower than that in the patients at stage Ⅲ and IV（P〈0.05）; lymph node metastasis： SAA levels in the patients with gastric cancer complicated with lymph node metastasis were signifi- cantly lower than those without lymph node metastasis（P〈0.05）; the differences of hs-CPR and CE
出处
《中国现代医生》
2017年第10期76-79,共4页
China Modern Doctor
基金
浙江省科技计划项目(2011C33045)
关键词
血清淀粉样蛋白A
胃癌
鉴定区别
早期诊断
Amyloid A
Gastric cancer
Differences of identification
Early diagnosis
