摘要
目的探讨血清淀粉样蛋白A在类风湿性关节炎(RA)中的临床价值。方法应用胶乳增强免疫比浊法对52例RA患者、54例痛风性关节炎患者和37例正常对照组的血清进行淀粉样蛋白A(SAA)、类风湿因子(RF)及C-反应蛋白(CRP)进行检测,并分析其诊断性能和相关性。结果 RA组SAA、RF高于痛风性关节炎组及正常对照组,差异均有统计学意义(P<0.05);RA组CRP与痛风性关节炎组比较,差异无统计学意义(P>0.05),但高于正常对照组,差异有统计学意义(P<0.05)。RF、SAA、CRP的曲线下面积分别为0.840、0.616、0.600。SAA与CRP、RF均呈正相关(r值分别为0.648、0.226,P<0.05)。结论 SAA可以作为一个评估RA疾病较好的标志物。
Objective To explore the clinical value of serum amyloid A（ SAA） in rheumatoid arthritis（ RA）. Methods Serums from 52 patients with RA,54 patients with goutyarthritis and 37 healthy controls（ HC） were conducted for the detection of SAA,serum C reactive protein（ CRP） and rheumatoid factor（ RF） by latex- enhanced immunoturbidimetric assay. And its diagnostic performance and correlation were analyzed. Results The SAA,RF levels of patients in RA group was higher than that of patients in goutyarthritis group and HC group,with the differences statistically significant（ P 〈 0. 05）. There was no statistical significance on the difference between the CRP group and the arthritis group,and the difference was statistically significant（ P 0. 05）; but it was higher than the control group,and the difference was statistically significant（ P 〈 0. 05）. The area under the curve of RF,SAA and CRP were respectively 0. 840,0. 616,0. 600. SAA was positively correlated with CRP and RF（ r =0. 648,r = 0. 226,P 〈 0. 05）. Conclusion SAA can be used as a marker to evaluate RA.
作者
项国谦
陈岳明
冯迪英
沈芸霓
XIANG Guo-qian CHEN Yue-ming FENG Di-ying SHEN Yun-ni(The First Hospital of Hangzhou（the First People＇s Hospital of Hangzhou） Affiliated to Zhejiang Chinese Medical University, Hangzhou , Zhejiang 310006, China)
出处
《中国卫生检验杂志》
CAS
2016年第20期2945-2946,共2页
Chinese Journal of Health Laboratory Technology
