摘要
目的评价在类风湿关节炎疾病中,抗环瓜氨酸肽抗体和类风湿因子联合检测所展现出来的临床诊断价值。方法选取丰顺县人民医院2019年9月至2020年2月收治的类风湿关节炎患者48例,按照随机数字表法分为对照组和观察组,每组24例。对照组患者采取抗环瓜氨酸肽抗体诊断方法,观察组患者采取抗环瓜氨酸肽抗体和类风湿因子联合检测方法。比较两组患者的阳性率、诊断灵敏度、特异度、阳性预测值、阴性预测值、X线表现。结果观察组患者的检测阳性率、灵敏度、阴性预测值高于对照组,特异度、阳性预测值低于对照组;观察组患者的骨质破坏率高于对照组,组间比较差异有统计学意义(P<0.05),而关节腔间隙增宽率低于对照组,软组织肿胀率、骨质增生率高于对照组,组间比较差异无统计学意义(P>0.05)。结论在类风湿关节炎疾病的诊断中,抗环瓜氨酸肽抗体和类风湿因子联合检测方法所展现出来的临床诊断价值显著优于单一使用抗环瓜氨酸肽抗体的诊断方法,阳性检出率更高。
Objective To evaluate the clinical diagnostic value of combined detection of anti cyclic citrullinated peptide antibody and rheumatoid factor in rheumatoid arthritis.Methods Totally 48 patients with rheumatoid arthritis admitted to Fengshun County People's Hospital from September 2019 to February 2020 were randomLy divided into control group and observation group,24 cases in each group.Patients in the control group were given the diagnostic method of anti cyclic citrullinated peptide antibody,and patients in the observation group were given the combined detection method of anti cyclic citrullinated peptide antibody and rheumatoid factor.The positive rate,diagnostic sensitivity,specificity,positive predictive value,negative predictive value and X-ray manifestations of the two groups were observed.Results The positive rate,sensitivity,and negative predictive value of the observation group were higher than those of the control group,and the specificity and positive predictive value were lower than those of the control group;the difference in bone destruction rate of the observation group was statistically significant(P<0.05),while the joint The rate of space widening was lower than that of the control group,and the rate of soft tissue swelling and bone hyperplasia was higher than that of the control group,but there was no significant difference between the groups(P>0.05).Conclusion In the diagnosis of rheumatoid arthritis,the combined detection of anti cyclic citrullinated peptide antibody and rheumatoid factor shows a better clinical diagnostic value than the single use of anti cyclic citrullinated peptide antibody.The positive detection rate is higher.
作者
陈敬好
黄银招
CHEN Jinghao;HUANG Yinzhao(Fengshun County People's Hospital,Meizhou,Guangdong 514300,China)
出处
《大医生》
2020年第11期38-40,共3页
Doctor
关键词
抗环瓜氨酸肽
抗体
类风湿因子
类风湿关节炎
阳性率
anti cyclic citrullinated peptide
antibody
rheumatoid factor
rheumatoid arthritis
positive rate
