摘要
目的探讨血清淀粉样蛋白A(Serum amyloid A)对胃癌的临床诊断价值。方法研究对象为78例胃癌患者(术后复发患者32例,未复发患者46例)和59例胃溃疡患者,并将54例同期健康体检者做为对照组。采用散射速率比浊法测定SAA和超敏C反应蛋白(hsCRP),电化学发光法测定癌胚抗原(CEA)。将胃癌和胃溃疡患者外周血中的三项指标的表达水平进行对照,并结合临床病理参数以及术后随访复发、未复发患者各指标的变化进行相关性分析。结果①胃癌、胃溃疡和对照组的年龄、性别构成比无统计学差异(P>0.05);与对照组比胃癌、胃溃疡组SAA水平显著升高,且胃癌组SAA水平显著高于胃溃疡组,差异有统计学意义(P<0.05);胃癌组CEA水平显著高于其它两组,差异有统计学意义(P<0.05)。②78例胃癌患者三项指标的不同年龄间,不同性别间均无统计学差异(P>0.05);T1至T4期SAA水平呈递增趋势,四期间呈正相关(r=0.716);TNM分期Ⅲ、Ⅳ期SAA水平显著高于Ⅰ、Ⅱ期(P=0.027);46例淋巴结转移患者SAA水平显著高于32例未转移患者(P=0.014);hsCRP、CEA水平与肿瘤浸润深度、TNM分期、有无淋巴结转移均无显著差异。③将胃癌患者术后复发与未复发SAA、hsCRP、CEA水平比较,hsCRP水平在未复发组手术前后变化无显著性差异(P>0.05),术后复发组SAA水平在显著高于术前,而术后未复发组SAA水平显著低于术前,差异有统计学意义(P<0.05)。④在胃癌患者中SAA与hsCRP呈正相关,r=0.736,P<0.05;SAA与CEA呈正相关,r=0.468,P<0.05。结论检测血清SAA水平对胃癌侵袭、转移的评估以及术后复发及预后具有一定临床价值,有助于胃癌的诊断。
Objective To investigate the value of serum amyloid A（SAA）in diagnosis of gastric cancer.Methods 78 patients with gastric cancer（32 patients with recurrence,46 patients without recurrence）,59 patients with gastric ulcer,and 54 healthy subjects regarded as control were enrolled in this study.SAA and hsCRP levels were measured using Rate nephelometry while Electro chemiluminescence immunoassay to CEA.Results ①There was no significant difference in the the structure of sexual distinction and ages between disease group and control group（P0.05）.Compared with the control group,the SAA levels of disease group was significantly higher,and the SAA levels in gastric cancer group was significantly higher than gastric ulcers group（P0.05）.CEA in gastric cancer group was significantly higher than in the other two groups（P0.05）.②There was no significant difference among the levels of SAA,hsCRP and CEA in the 78 cases of gastric cancer patients.The SAA levels showed an increasing trend from stage T1 to stage T4,and was positive correlate with the depth of invasion（r=0.716）;for TNM stage,the SAA levels of Ⅲ,Ⅳ stage was significantly higher than Ⅰ,Ⅱ stage（P=0.027）;the SAA levels in 46 patients with lymph nodes with metastasis was also higher than the 32 patients with no lymph nodes with metastasis（P=0.014）.③The level of hsCRP does not lead to distinctive different perioperatively in group without recurrence（P0.05）,the SAA levels of recurrence group was higher than preoperative views while the SAA levels of group with no recurrence was lower than preoperative views too（P0.05）.④In patients with gastric cancer,SAA was positive correlate with hsCRP,r=0.736,P0.05;also SAA was positive correlate with CEA,r=0.468,P0.05.Conclusion Determination of SAA in serum is useful to the prognosis and diagnosis of gastric cancer.
出处
《中国实验诊断学》
北大核心
2011年第7期1073-1076,共4页
Chinese Journal of Laboratory Diagnosis
基金
江西省科技厅科技支撑计划项目(2007BS23109)
关键词
胃癌
血清淀粉样蛋白A
超敏C反应蛋白
癌胚抗原
gastric cancer
serum amyloid A
high sensitivity C reactive protein
carcinoembryonic antigen
